Three new sesquiterpenoids from agarwood of Aquilaria crassna

被引：29

作者：

Wang, Hong-Ni ^{[1
,2
]}

Dong, Wen-Hua ^{[1
]}

Huang, Sheng-Zhuo ^{[1
]}

Li, Wei ^{[1
]}

Kong, Fan-Dong ^{[1
]}

Wang, Hao ^{[1
]}

Wang, Jun ^{[1
]}

Mei, Wen-Li ^{[1
]}

Dai, Hao-Fu ^{[1
]}

机构：

[1] Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Key Lab Biol & Genet Resources Trop Crops, Minist Agr, Haikou 571101, Peoples R China

[2] Hainan Univ, Hort & Garden Coll, Haikou 570228, Peoples R China

来源：

FITOTERAPIA | 2016年 / 114卷

关键词：

Aquilaria crassna; Agarwood; Sesquiterpenoid; Acetylcholinesterase inhibition activity; Antibacterial activity; 2-(2-PHENYLETHYL)CHROMONE DERIVATIVES; A-D; SINENSIS;

D O I：

10.1016/j.fitote.2016.07.014

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three new sesquiterpenoids (1-3), together with two known ones were isolated from the EtOAc extract of agarwood originating from Aquilaria crassna. The new compounds were elucidated on the basis of spectroscopic techniques (UV, IR, MS, 1D and 2D NMR). Compounds 1-5 were isolated from agarwood of A. crassna for the first time. In the acetylcholinesterase inhibition experiment of 2-5, compound 3 showed acetylcholinesterase inhibition activity (IR 42.9 +/- 0.6%). Compound 5 expressed antibacterial activities against Staphylococcus aureus and Ralstonia solanacearum with diameter of the inhibition zones of 12.35 +/- 0.11 mm and 16.90 +/- 0.09 mm, respectively. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：7 / 11

页数：5

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