Borano-nucleotides: New analogues to circumvent HIV-1 RT-mediated nucleoside drug-resistance

被引：9
|
作者：
Alvarez, K
Deval, J
Selmi, B
Barral, K
Boretto, J
Guerreiro, C
Mulard, L
Sarfati, R
Canard, B
机构：
[1] CNRS, UMR 6098, ESIL, F-13288 Marseille, France
[2] Inst Pasteur, Unite Chim Organ, Paris 15, France
来源：
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2005年 / 24卷 / 5-7期
关键词：
D O I：
10.1081/NCN-200059951
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
alpha-Boranophosphates suppress RT-mediated resistance when the catalytic rate of incorporation (k(pol))of the analogue 5'-triphosphate is responsable for drug resistance, such as in the case of K65R mutant and ddNTPs, and Q151M toward AZTTP and ddNTPs. This suppression is also observed with BH(3)d4T and BH3-3TC toward their clinically relevant mutants Q151M and M184V Moreover, the presence of the borano (BH3-) group renders the incorporation of the analogue independent from amino-acid substitutions in RT To our knowledge, this is the first example of rescue of polymerase activity by means of a nucleotide analogue.
引用
收藏
页码：419 / 421
页数：3
相关论文
共 50 条
  • [41] Nucleotide substitution patterns can predict the requirements for drug-resistance of HIV-1 proteins
    Keulen, W
    Boucher, C
    Berkhout, B
    ANTIVIRAL RESEARCH, 1996, 31 (1-2) : 45 - 57
  • [42] Development and Evaluation of a National Reference Panel of HIV-1 Protease and Reverse Transcriptase Drug-Resistance Mutations for HIV-1 Genotypic Resistance Assays in China
    Sihong Xu
    Jingyun Li
    Zuoyi Bao
    Hui Xing
    Ping Zhong
    Hanping Li
    Haiwei Zhou
    Xinping Li
    Sharon Wu
    Aijing Song
    Xiuhua Li
    Jianhui Nie
    Youchun Wang
    Molecular Diagnosis & Therapy, 2010, 14 : 31 - 41
  • [43] Development and Evaluation of a National Reference Panel of HIV-1 Protease and Reverse Transcriptase Drug-Resistance Mutations for HIV-1 Genotypic Resistance Assays in China
    Xu, Sihong
    Li, Jingyun
    Bao, Zuoyi
    Xing, Hui
    Zhong, Ping
    Li, Hanping
    Zhou, Haiwei
    Li, Xinping
    Wu, Sharon
    Song, Aijing
    Li, Xiuhua
    Niel, Jianhui
    Wang, Youchun
    MOLECULAR DIAGNOSIS & THERAPY, 2010, 14 (01) : 31 - 41
  • [44] Crystal structure of HIV-1 reverse transcriptase (RT)/dsDNA/non-nucleoside inhibitor complex for understanding inhibition and drug resistance
    Das, K.
    Martinez, S. E.
    Arnold, E.
    ANTIVIRAL THERAPY, 2011, 16 : A56 - A56
  • [45] Comparative Evaluation of the ViroSeq™ HIV-1 Genotyping System and an In-House Method for Analysis of HIV-1 Drug-Resistance Mutations in China
    Xu, Sihong
    Zhong, Ping
    Li, Jingyun
    Song, Aijing
    Li, Hanping
    Nie, Jianhui
    Li, Xiuhua
    Wang, Youchun
    MOLECULAR DIAGNOSIS & THERAPY, 2011, 15 (01) : 41 - 52
  • [46] Comparative Evaluation of the ViroSeq™ HIV-1 Genotyping System and an In-House Method for Analysis of HIV-1 Drug-Resistance Mutations in China
    Sihong Xu
    Ping Zhong
    Jingyun Li
    Aijing Song
    Hanping Li
    Jianhui Nie
    Xiuhua Li
    Youchun Wang
    Molecular Diagnosis & Therapy, 2011, 15 : 41 - 52
  • [47] Measuring Enzymatic HIV-1 Susceptibility to Two Reverse Transcriptase Inhibitors as a Rapid and Simple Approach to HIV-1 Drug-Resistance Testing
    Hoffmann, Dieter
    Garcia, Albert D.
    Harrigan, P. Richard
    Johnston, Ian C. D.
    Nakasone, Tadashi
    Garcia-Lerma, J. Gerardo
    Heneine, Walid
    PLOS ONE, 2011, 6 (07):
  • [48] HIV-1 integrase drug-resistance mutations in Iranian treatment-experienced HIV-1-infected patients
    Marjani, Arezoo
    Bokharaei-Salim, Farah
    Jahanbakhshi, Fatemeh
    Monavari, Seyed Hamidreza
    Esghaei, Maryam
    Kalantari, Saeed
    Kiani, Seyed Jalal
    Ataei-Pirkooh, Angila
    Fakhim, Atousa
    Keyvani, Hossein
    ARCHIVES OF VIROLOGY, 2020, 165 (01) : 115 - 125
  • [49] HIV-1 integrase drug-resistance mutations in Iranian treatment-experienced HIV-1-infected patients
    Arezoo Marjani
    Farah Bokharaei-Salim
    Fatemeh Jahanbakhshi
    Seyed Hamidreza Monavari
    Maryam Esghaei
    Saeed Kalantari
    Seyed Jalal Kiani
    Angila Ataei-Pirkooh
    Atousa Fakhim
    Hossein Keyvani
    Archives of Virology, 2020, 165 : 115 - 125
  • [50] Identification of RT mutations associated with HIV-1 drug resistance in treatment naive patients
    Magiorkinis, E
    Paraskevis, D
    Lazanas, M
    Kiosses, VG
    Gargalianos, P
    Hatzakis, A
    AIDS, 1998, 12 : S25 - S25
12345