An acoustic on-chip goniometer for room temperature macromolecular crystallography

被引：1

作者：

Burton, C. G. ^{[1
]}

Axford, D. ^{[2
]}

Edwards, A. M. J. ^{[3
]}

Gildea, R. J. ^{[2
]}

Morris, R. H. ^{[3
]}

Newton, M. I. ^{[3
]}

Orville, A. M. ^{[4
,5
]}

Prince, M. ^{[1
]}

Topham, P. D. ^{[1
]}

Docker, P. T. ^{[2
]}

机构：

[1] Aston Univ, Aston Inst Mat Res, Birmingham B4 7ET, W Midlands, England

[2] Diamond Light Source, Harwell Sci & Innovat Campus, Didcot OX11 0DE, Oxon, England

[3] Nottingham Trent Univ, Sch Sci & Technol, Clifton Lane, Nottingham NG11 8NS, England

[4] Res Complex Harwell, Harwell Sci & Innovat Campus, Didcot OX11 0DE, Oxon, England

[5] Diamond Light Source, Harwell Sci & Innovat Campus, Didcot OX11 0DE, Oxon, England

来源：

LAB ON A CHIP | 2017年 / 17卷 / 24期

基金：

英国惠康基金; “创新英国”项目; 英国生物技术与生命科学研究理事会;

关键词：

SERIAL FEMTOSECOND CRYSTALLOGRAPHY; PROTEIN CRYSTALLOGRAPHY; DIFFRACTION; MICROFLUIDICS;

D O I：

10.1039/c7lc00812k

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

This paper describes the design, development and successful use of an on-chip goniometer for room-temperature macromolecular crystallography via acoustically induced rotations. We present for the first time a low cost, rate-tunable, acoustic actuator for gradual in-fluid sample reorientation about varying axes and its utilisation for protein structure determination on a synchrotron beamline. The device enables the efficient collection of diffraction data via a rotation method from a sample within a surface confined droplet. This method facilitates efficient macromolecular structural data acquisition in fluid environments for dynamical studies.

引用

页码：4225 / 4230

页数：6

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