Molecular virology of hepatitis E virus

被引：212
|
作者：
Ahmad, Imran [1 ]
Holla, R. Prasida [1 ]
Jameel, Shahid [1 ]
机构：
[1] Int Ctr Genet Engn & Biotechnol, Virol Grp, New Delhi, India
来源：
VIRUS RESEARCH | 2011年 / 161卷 / 01期
基金：
美国国家卫生研究院; 英国惠康基金;
关键词：
HEV; ORF1; ORF2; ORF3; RNA replication; ORF3; PROTEIN; CAPSID PROTEIN; MONOCLONAL-ANTIBODIES; MUTATIONAL ANALYSIS; CYNOMOLGUS MONKEYS; HEPATOMA-CELLS; RHESUS-MONKEYS; CDNA-CLONE; RNA; HEV;
D O I：
10.1016/j.virusres.2011.02.011
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
This review details the molecular virology of the hepatitis E virus (HEV). While replicons and in vitro infection systems have recently become available, a lot of information on HEV has been generated through comparisons with better-studied positive-strand RNA viruses and through subgenomic expression of viral open reading frames. These models are now being verified with replicon and infection systems. We provide here the current knowledge on the HEV genome and its constituent proteins - ORF1, ORF2 and ORF3. Based on the available information, we also modify the existing model of the HEV life cycle. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：47 / 58
页数：12
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