Molecular Virology of Hepatitis E Virus

被引：103

作者：

Holla, R. Prasida ^{[1
]}

Ahmad, Imran ^{[1
]}

Ahmad, Zulfazal ^{[1
]}

Jameel, Shahid ^{[1
]}

机构：

[1] ICGEB, Virol Grp, New Delhi 110067, India

来源：

SEMINARS IN LIVER DISEASE | 2013年 / 33卷 / 01期

基金：

美国国家卫生研究院; 英国惠康基金;

关键词：

hepatitis E; HEV; ORF1; ORF2; ORF3; RNA replication; NON-B-HEPATITIS; TRANSMITTED NON-A; ORF3; PROTEIN; VIRAL-RNA; MUTATIONAL ANALYSIS; CYNOMOLGUS MONKEYS; RIBAVIRIN THERAPY; HEPATOMA-CELLS; CAPSID PROTEIN; RHESUS-MONKEYS;

D O I：

10.1055/s-0033-1338110

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Hepatitis E virus (HEV) is the causative agent of hepatitis E. It is a nonenveloped virus with a similar to 7.2 kilobases positive-stranded RNA genome. The molecular virology of HEV is getting better understood with the development of replicons and in vitro infection systems, and the discovery of related viruses that infect animal species other than humans. This review focuses on the virology of HEV and updates the current knowledge on the HEV genome and its constituent proteins-ORF1, ORF2, and ORF3, and the viral life cycle.

引用

页码：3 / 14

页数：12

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