Palladium-Catalyzed Cross-Coupling between 7-Azaindoles and Reformatsky Reagents

被引：9
|
作者：
Barl, Nadja M. [1 ]
Malakhov, Vladimir [1 ]
Mathes, Christian [2 ]
Lustenberger, Philipp [2 ]
Knochel, Paul [1 ]
机构：
[1] Univ Munich, Dept Chem & Biochem, D-81377 Munich, Germany
[2] Novartis Pharma AG, CH-4056 Basel, Switzerland
来源：
SYNTHESIS-STUTTGART | 2015年 / 47卷 / 05期
基金：
欧洲研究理事会;
关键词：
azaindole; Reformatsky reagents; metalation; palladium; cross-coupling; FUNCTIONALIZED ORGANOZINC REAGENTS; INHIBITORY-ACTIVITY; CARBON-DIOXIDE; ZINCATION; REACTIVITY; AZAINDOLES; ALDEHYDES; HALIDES; KETONES; POTENT;
D O I：
10.1055/s-0034-1379459
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The preparation of various 2-(7-azaindolyl)carboxylic esters by Pd-catalyzed coupling of Reformatsky reagents with TBDMS-protected 3-bromo-7-azaindoles leading to a wide range of arylated ester derivatives is reported. After removal of the protecting group, the corresponding free 2-(7-azaindolyl)carboxylic esters are obtained in satisfactory yields.
引用
收藏
页码：692 / 700
页数：9
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