Canonical and Non-Canonical Wnt Signaling in Immune Cells

被引：131
|
作者：
Chae, Wook-Jin [1 ]
Bothwell, Alfred L. M. [1 ]
机构：
[1] Yale Univ, Sch Med, Dept Immunobiol, 300 Cedar St, New Haven, CT 06520 USA
来源：
TRENDS IN IMMUNOLOGY | 2018年 / 39卷 / 10期
基金：
美国国家卫生研究院;
关键词：
REGULATORY T-CELLS; FOLLICULAR HELPER-CELLS; BETA-CATENIN; DENDRITIC CELLS; BREAST-CANCER; ANTAGONIST DICKKOPF-1; SUPPRESSIVE FUNCTION; VIRAL-INFECTION; STEM-CELLS; PROMOTES;
D O I：
10.1016/j.it.2018.08.006
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Cell differentiation, proliferation, and death are vital for immune homeostasis. Wnt signaling plays essential roles in processes across species. The roles of Wnt signaling proteins and Wnt ligands have been studied in the past, but the context-dependent mechanisms and functions of these pathways in immune responses remain unclear. Recent findings regarding the role of Wnt ligands and Wnt signaling in immune cells and their immunomodulatory mechanisms suggest that Wnt ligands and signaling are significant in regulating immune responses. We introduce recent key findings and future perspectives on Wnt ligands and their signaling pathways in immune cells as well as the immunological roles and functions of Wnt antagonists.
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页码：830 / 847
页数：18
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