Detection of Actionable BCR-ABL1 Kinase Domain (KD) Mutations in Chronic Myeloid Leukemia (CML) Patients with Failure and Warning Response to Tyrosine Kinase Inhibitors (TKIs): Potential Impact of Next-Generation Sequencing (NGS) and Droplet Digital PCR (ddPCR) on Clinical Decision Making

被引：6

作者：

Soverini, Simona ^{[1
]}

Martelli, Margherita ^{[1
]}

Bavaro, Luana ^{[1
]}

De Benedittis, Caterina ^{[1
]}

Iurlo, Alessandra ^{[2
]}

Galimberti, Sara ^{[3
]}

Pregno, Patrizia ^{[4
]}

Bonifacio, Massimiliano ^{[5
]}

Lunghi, Francesca ^{[6
]}

Castagnetti, Fausto ^{[1
]}

Gugliotta, Gabriele ^{[1
]}

Rosti, Gianantonio ^{[1
]}

Tiribelli, Mario ^{[7
]}

Velotta, Vanessa ^{[8
]}

Stagno, Fabio ^{[9
,10
]}

Rossi, Antonella Russo ^{[11
]}

D'Adda, Mariella ^{[12
]}

Barate, Claudia ^{[13
]}

Crugnola, Monica ^{[14
]}

Luciano, Luigiana ^{[15
]}

Laginestra, Maria Antonella ^{[16
]}

Corner, Adam S. ^{[17
]}

Maar, Dianna ^{[17
]}

Percesepe, Antonio ^{[18
]}

Pileri, Stefano ^{[19
]}

Pane, Fabrizio ^{[20
]}

Saglio, Giuseppe ^{[21
]}

Baccarani, Michele ^{[22
]}

Martinelli, Giovanni ^{[23
]}

Cavo, Michele ^{[24
]}

机构：

[1] Univ Bologna, Inst Hematol LeA Seragnoli, Bologna, Italy

[2] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Div Hematol, Milan, Italy

[3] Univ Pisa, Dept Hematol, Pisa, Italy

[4] Az Osped Univ Citta Salute & Sci, Hematol Unit, Turin, Italy

[5] Univ Verona, Sect Hematol, Dept Med, Verona, Italy

[6] San Raffaele Sci Inst IRCCS, Hematol & Bone Marrow Transplant Unit, Milan, Italy

[7] Univ Udine, Div Hematol & BMT, Dept Med Area, Udine, Italy

[8] ASL Roma2, Rome, Italy

[9] AOU Policlin V Emanuele, Hematol Sect, Catania, Italy

[10] AOU Policlin V Emanuele, BMT Unit, Catania, Italy

[11] Univ Bari, Hematol, Bari, Italy

[12] ASST Spedali Civili Brescia, Dept Hematol, Brescia, Italy

[13] Univ Pisa, Dept Clin & Expt Med, Hematol, Pisa, Italy

[14] Azienda Osped Univ Parma, Div Hematol, Parma, Italy

[15] Univ Naples Federico II, Dept Clin Med & Surg, Naples, Italy

[16] Hematopathol Sect, Dept Expt Diagnost & Specialty Med, Bologna, Italy

[17] Digital Biol Grp, Bio Rad Labs, Peterborough, Cambs, England

[18] Univ Parma, Dept Med & Surg, Med Genet Unit, Parma, Italy

[19] European Inst Oncol, Hematopathol Unit, Milan, Italy

[20] Univ Naples Federico II, Hematol Unit, Naples, Italy

[21] AO Ordine Mauriziano, Div Univ Ematol & Terapie Cellulari, Turin, Italy

[22] St Orsola Hosp, Inst Hematol L&A Seragnoli, Bologna, Italy

[23] IRST IRCCS, Meldola, Italy

[24] Univ Bologna, Inst Hematol L&A Seragnoli, Dept Expt Diagnost & Specialty Med, Bologna, Italy

来源：

BLOOD | 2019年 / 134卷

关键词：

D O I：

10.1182/blood-2019-126767

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

661

引用

页数：6

共 33 条

[31] Comparison of Molecular Responses between e14a2 and e13a2 BCR-ABL1 Transcripts in Patients with Chronic Myeloid Leukemia in Chronic Phase Treated with Front-Line Second Generation Tyrosine Kinase Inhibitors: Taiwan CML Study
Su, Yi-Jiun
Kuo, Ming-Chung
Teng, Chieh-Lin
Chen, Tsai-Yun
Ma, Ming-Chun
Hsiao, Pei-Ching
Wang, Ming-Chung
Lin, Tung-Huei
Hwang, Wen-Li
Chen, Chih-Cheng
Yang, Youngsen
Pei, Sung-Nan
Huang, Yen-Min
Li, Sin-Syue
Lee, Ming-Yang
Cheng, Hung-I
Shih, Lee-Yung
BLOOD, 2017, 130
[32] BCR-ABL1 Transcript Levels at 3 and 6 Months Are Better for Identifying Chronic Myeloid Leukemia Patients with Poor Outcome in Response to Second-Line Second-Generation Tyrosine Kinase Inhibitors after Imatinib Failure: A Report from a Single Institution
Ribeiro, Beatriz Felicio
Vergilio, Bruna Rocha
Martins Miranda, Eliana Cristina
Almeida, Maria Helena
Delamain, Marcia Torresan
da Silveira, Rosana Antunes
de Souza, Carmino Antonio
Albuquerque, Dulcineia Martins
Dos Santos, Andrey
Duarte, Vagner Oliveira
Oliveira-Duarte, Gislaine Borba
Lorand-Metze, Irene
Barbosa Pagnano, Katia Borgia
ACTA HAEMATOLOGICA, 2015, 134 (04) : 248 - 254
[33] Digital PCR (dPCR) Overcomes the Limitations in Detection and in Quantification of Quantitative PCR (qPCR) and Reveals Different Levels of BCR-ABL1 Copies/μl Among the Chronic Myeloid Leukemia (CML) Patients Achieving Major (MR3.0) or DEEP (MR4.0, MR4.5 and MR5.0) Molecular Response with Tyrosin Kynase Inhibitors (TKls)
Bernardi, Simona
Di Palma, Andrea
Tiribelli, Mario
Codarin, Erika
Ruggeri, Giuseppina
Bochicchio, Maria Teresa
Malagola, Michele
Cattina, Federica
Perucca, Simone
Cancelli, Valeria
Skert, Crisitina
Rosti, Gianatonio
Castagnetti, Fausto
Caimi, Luigi
Rossi, Giuseppe
Martinelli, Giovanni
Russo, Domenico
BLOOD, 2015, 126 (23)

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