Detection of Actionable BCR-ABL1 Kinase Domain (KD) Mutations in Chronic Myeloid Leukemia (CML) Patients with Failure and Warning Response to Tyrosine Kinase Inhibitors (TKIs): Potential Impact of Next-Generation Sequencing (NGS) and Droplet Digital PCR (ddPCR) on Clinical Decision Making

被引：6

作者：

Soverini, Simona ^{[1
]}

Martelli, Margherita ^{[1
]}

Bavaro, Luana ^{[1
]}

De Benedittis, Caterina ^{[1
]}

Iurlo, Alessandra ^{[2
]}

Galimberti, Sara ^{[3
]}

Pregno, Patrizia ^{[4
]}

Bonifacio, Massimiliano ^{[5
]}

Lunghi, Francesca ^{[6
]}

Castagnetti, Fausto ^{[1
]}

Gugliotta, Gabriele ^{[1
]}

Rosti, Gianantonio ^{[1
]}

Tiribelli, Mario ^{[7
]}

Velotta, Vanessa ^{[8
]}

Stagno, Fabio ^{[9
,10
]}

Rossi, Antonella Russo ^{[11
]}

D'Adda, Mariella ^{[12
]}

Barate, Claudia ^{[13
]}

Crugnola, Monica ^{[14
]}

Luciano, Luigiana ^{[15
]}

Laginestra, Maria Antonella ^{[16
]}

Corner, Adam S. ^{[17
]}

Maar, Dianna ^{[17
]}

Percesepe, Antonio ^{[18
]}

Pileri, Stefano ^{[19
]}

Pane, Fabrizio ^{[20
]}

Saglio, Giuseppe ^{[21
]}

Baccarani, Michele ^{[22
]}

Martinelli, Giovanni ^{[23
]}

Cavo, Michele ^{[24
]}

机构：

[1] Univ Bologna, Inst Hematol LeA Seragnoli, Bologna, Italy

[2] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Div Hematol, Milan, Italy

[3] Univ Pisa, Dept Hematol, Pisa, Italy

[4] Az Osped Univ Citta Salute & Sci, Hematol Unit, Turin, Italy

[5] Univ Verona, Sect Hematol, Dept Med, Verona, Italy

[6] San Raffaele Sci Inst IRCCS, Hematol & Bone Marrow Transplant Unit, Milan, Italy

[7] Univ Udine, Div Hematol & BMT, Dept Med Area, Udine, Italy

[8] ASL Roma2, Rome, Italy

[9] AOU Policlin V Emanuele, Hematol Sect, Catania, Italy

[10] AOU Policlin V Emanuele, BMT Unit, Catania, Italy

[11] Univ Bari, Hematol, Bari, Italy

[12] ASST Spedali Civili Brescia, Dept Hematol, Brescia, Italy

[13] Univ Pisa, Dept Clin & Expt Med, Hematol, Pisa, Italy

[14] Azienda Osped Univ Parma, Div Hematol, Parma, Italy

[15] Univ Naples Federico II, Dept Clin Med & Surg, Naples, Italy

[16] Hematopathol Sect, Dept Expt Diagnost & Specialty Med, Bologna, Italy

[17] Digital Biol Grp, Bio Rad Labs, Peterborough, Cambs, England

[18] Univ Parma, Dept Med & Surg, Med Genet Unit, Parma, Italy

[19] European Inst Oncol, Hematopathol Unit, Milan, Italy

[20] Univ Naples Federico II, Hematol Unit, Naples, Italy

[21] AO Ordine Mauriziano, Div Univ Ematol & Terapie Cellulari, Turin, Italy

[22] St Orsola Hosp, Inst Hematol L&A Seragnoli, Bologna, Italy

[23] IRST IRCCS, Meldola, Italy

[24] Univ Bologna, Inst Hematol L&A Seragnoli, Dept Expt Diagnost & Specialty Med, Bologna, Italy

来源：

BLOOD | 2019年 / 134卷

关键词：

D O I：

10.1182/blood-2019-126767

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

661

引用

页数：6

共 33 条

[1] Deep sequencing of BCR-ABL1 kinase domain mutations in chronic myeloid leukemia patients with resistance to tyrosine kinase inhibitors
Erbilgin, Yucel
Eskazan, Ahmet Emre
Ng, Ozden Hatirnaz
Salihoglu, Ayse
Elverdi, Tugrul
Firtina, Sinem
Tasar, Orcun
Mercan, Sevcan
Sisko, Sinem
Khodzhaev, Khusan
Ongoren, Seniz
Ar, Muhlis Cem
Baslar, Zafer
Soysal, Teoman
Sayitoglu, Muge
Ozbek, Ugur
LEUKEMIA & LYMPHOMA, 2019, 60 (01) : 200 - 207
[2] Next-Generation Sequencing Of The BCR-ABL1 Domain May Be Beneficial In Decision Making Among Chronic Myeloid Leukemia Patients With Tyrosine Kinase Inhibitor Resistance
Erbilgin, Yucel
Eskazan, Ahmet Emre
Ng, Ozden Hatirnaz
Salihoglu, Ayse
Elverdi, Tugrul
Firtina, Sinem
Tatonyan, Suzin Catal
Aydin, Seniz Ongoren
Ar, Muhlis Cem
Baslar, Zafer
Sayitoglu, Muge
Ferhanoglu, A. Burhan
Aydin, Yildiz
Ozbek, Ugur
Soysal, Teoman
BLOOD, 2013, 122 (21)
[3] DETECTION AND MONITORING OF BCR-ABL1 KINASE DOMAIN MUTATIONS IN CML AND ALL PATIENTS BY NEXT GENERATION SEQUENCING AND DROPLET DIGITAL PCR, A BELGIAN PROSPECTIVE STUDY
De Rop, C.
Devos, H.
Vannuffel, P.
Nollet, F.
HAEMATOLOGICA, 2017, 102 : 434 - 435
[4] Next-generation deep sequencing improves detection of BCR-ABL1 kinase domain mutations emerging under tyrosine kinase inhibitor treatment of chronic myeloid leukemia patients in chronic phase
Katerina Machova Polakova
Vojtech Kulvait
Adela Benesova
Jana Linhartova
Hana Klamova
Monika Jaruskova
Caterina de Benedittis
Torsten Haferlach
Michele Baccarani
Giovanni Martinelli
Tomas Stopka
Thomas Ernst
Andreas Hochhaus
Alexander Kohlmann
Simona Soverini
Journal of Cancer Research and Clinical Oncology, 2015, 141 : 887 - 899
[5] Next-generation deep sequencing improves detection of BCR-ABL1 kinase domain mutations emerging under tyrosine kinase inhibitor treatment of chronic myeloid leukemia patients in chronic phase
Polakova, Katerina Machova
Kulvait, Vojtech
Benesova, Adela
Linhartova, Jana
Klamova, Hana
Jaruskova, Monika
de Benedittis, Caterina
Haferlach, Torsten
Baccarani, Michele
Martinelli, Giovanni
Stopka, Tomas
Ernst, Thomas
Hochhaus, Andreas
Kohlmann, Alexander
Soverini, Simona
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2015, 141 (05) : 887 - 899
[6] Next-generation sequencing for BCR-ABL1 kinase domain mutation testing in patients with chronic myeloid leukemia: a position paper
Simona Soverini
Elisabetta Abruzzese
Monica Bocchia
Massimiliano Bonifacio
Sara Galimberti
Antonella Gozzini
Alessandra Iurlo
Luigiana Luciano
Patrizia Pregno
Gianantonio Rosti
Giuseppe Saglio
Fabio Stagno
Mario Tiribelli
Paolo Vigneri
Giovanni Barosi
Massimo Breccia
Journal of Hematology & Oncology, 12
[7] Next-generation sequencing for BCR-ABL1 kinase domain mutation testing in patients with chronic myeloid leukemia: a position paper
Soverini, Simona
Abruzzese, Elisabetta
Bocchia, Monica
Bonifacio, Massimiliano
Galimberti, Sara
Gozzini, Antonella
Iurlo, Alessandra
Luciano, Luigiana
Pregno, Patrizia
Rosti, Gianantonio
Saglio, Giuseppe
Stagno, Fabio
Tiribelli, Mario
Vigneri, Paolo
Barosi, Giovanni
Breccia, Massimo
JOURNAL OF HEMATOLOGY & ONCOLOGY, 2019, 12 (01)
[8] Discontinuation of tyrosine kinase inhibitors based on BCR-ABL1 monitoring by digital droplet PCR in pediatric chronic myeloid leukemia
Kim, Yeojae
Kim, Seongkoo
Lee, Jong Mi
Ahn, Ari
Yoo, Jae Won
Lee, Jae Wook
Cho, Bin
Chung, Nack-Gyun
Kim, Yonggoo
Kim, Myungshin
FRONTIERS IN PEDIATRICS, 2022, 10
[9] Droplet digital PCR for the detection of second-generation tyrosine kinase inhibitor-resistant BCR::ABL1 kinase domain mutations in chronic myeloid leukemia
Simona Soverini
Sara De Santis
Margherita Martelli
Cecilia Monaldi
Fausto Castagnetti
Gabriele Gugliotta
Cristina Papayannidis
Manuela Mancini
Samantha Bruno
Claudia Venturi
Katerina Machova Polakova
Thomas Ernst
Dianna Maar
Adam Corner
Michele Cavo
Leukemia, 2022, 36 : 2250 - 2260
[10] Droplet digital PCR for the detection of second-generation tyrosine kinase inhibitor-resistant BCR::ABL1 kinase domain mutations in chronic myeloid leukemia
Soverini, Simona
De Santis, Sara
Martelli, Margherita
Monaldi, Cecilia
Castagnetti, Fausto
Gugliotta, Gabriele
Papayannidis, Cristina
Mancini, Manuela
Bruno, Samantha
Venturi, Claudia
Polakova, Katerina Machova
Ernst, Thomas
Maar, Dianna
Corner, Adam
Cavo, Michele
LEUKEMIA, 2022, 36 (09) : 2250 - 2260

← 1 2 3 4 →