Cyclocondensation versus Cyclocondensation Plus Dehydroxylation During the Reaction of Flavones and Hydrazine

被引：6
|
作者：
Solis, Carlos M. [1 ]
Salazar, Mario O. [1 ,2 ]
Ayelen Ramallo, I [1 ,2 ]
Garcia, Paula [1 ]
Furlan, Ricardo L. E. [1 ,2 ]
机构：
[1] Univ Nacl Rosario, Fac Ciencias Bioquim & Farmaceut, Suipacha 531, RA-2000 Rosario, Argentina
[2] Consejo Nacl Invest Cient & Tecn, Suipacha 531, RA-2000 Rosario, Argentina
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 2022卷 / 25期
关键词：
Dehydroxylation; Flavone; Pyrazole; Tautomerism; Tyrosinase; INHIBITOR;
D O I：
10.1002/ejoc.202200455
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Concomitant selective dehydroxylation during the transformation of flavones into pyrazoles with hydrazine is determined by the A-ring substitution pattern and propensity to keto enol tautomerization. The obtained pyrazoles show varied tyrosinase inhibition properties, including one nanomolar inhibitor.
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页数：7
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