PANCREATIC CANCER Exosomes for targeting KRAS in the treatment of pancreatic cancer

被引：12
|
作者：
Buscail, Louis [1 ,2 ,3 ]
机构：
[1] CHU Toulouse, Dept Gastroenterol, Ctr Clin Invest Biotherapy, Rangueil Hosp, 1 Ave Jean Poulhes,TSA 50032, F-31059 Toulouse, France
[2] CHU Toulouse, INSERM, U1037, Rangueil Hosp, 1 Ave Jean Poulhes,TSA 50032, F-31059 Toulouse, France
[3] Univ Toulouse 3, 1 Ave Jean Poulhes,TSA 50032, F-31059 Toulouse, France
来源：
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY | 2017年 / 14卷 / 11期
关键词：
D O I：
10.1038/nrgastro.2017.113
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
KRAS oncogene mutations are commonly encountered in pancreatic ductal adenocarcinoma, driving tumour initiation, proliferation, progression and metastasis. Human exosomes engineered to deliver small interfering RNA silencing KRASG12D are highly efficient at specifically targeting pancreatic cancer cells to dramatically reduce RAS activation, cancer cell proliferation and metastatic processes.
引用
收藏
页码：636 / 637
页数：2
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