Removal of Amitriptyline from Simulated Gastric and Intestinal Fluids Using Activated Carbons

被引：9
|
作者：
Valente Nabais, Joao M. [1 ]
Ledesma, Beatriz
Laginhas, Carlos
机构：
[1] Univ Evora, Dept Quim, P-7000 Evora, Portugal
来源：
JOURNAL OF PHARMACEUTICAL SCIENCES | 2011年 / 100卷 / 12期
关键词：
nanoparticles; gastrointestinal; elimination; biomaterials; adsorption; activated carbon; amitriptyline; drug overdose; CHARCOAL;
D O I：
10.1002/jps.22757
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
In this work, the adsorption behavior of a tricyclic antidepressant, amitriptyline hydrochloride, onto several activated carbons (ACs) is reported. The adsorption was done using in vitro simulated gastric and intestinal fluid at 37 degrees C to test the performance of the carbons as treatment in overdose cases. The tested materials were one commercial AC (carbomix) and two ACs produced in our laboratory. The highest adsorption capacity was achieved by carbomix, followed by the laboratory-made carbons that still have a very good performance with adsorption capacity up to 120 and 100 mg/g for the gastric and intestinal fluids, respectively. (C) 2011 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 100:5096-5099, 2011
引用
收藏
页码：5096 / 5099
页数：4
相关论文
共 50 条
  • [21] Inexpensive activated carbons for the removal of dyes from wastewater
    Caglar, Atila
    ENERGY EDUCATION SCIENCE AND TECHNOLOGY PART A-ENERGY SCIENCE AND RESEARCH, 2009, 23 (1-2): : 119 - 133
  • [22] Inexpensive activated carbons for the removal of dyes from wastewater
    Caglar, Atila
    Energy Education Science and Technology Part A: Energy Science and Research, 2009, 23 (02): : 119 - 133
  • [23] Removal of naphthalene by activated carbons from hot gas
    Di Gregorio, F.
    Parrillo, F.
    Salzano, E.
    Cammarota, F.
    Arena, U.
    CHEMICAL ENGINEERING JOURNAL, 2016, 291 : 244 - 253
  • [24] Mercury removal from water using activated carbons derived from organic sewage sludge
    Zhang, FS
    Nriagu, JO
    Itoh, H
    WATER RESEARCH, 2005, 39 (2-3) : 389 - 395
  • [25] Study of the Mechanisms Involved in the Adsorption of Amitriptyline from Aqueous Solution onto Activated Carbons
    Ledesma, B.
    Roman, S.
    Gonzalez, J. F.
    Zamora, F.
    Rayo, M. C.
    ADSORPTION SCIENCE & TECHNOLOGY, 2010, 28 (8-9) : 739 - 750
  • [26] Adsorption of progesterone onto microplastics and its desorption in simulated gastric and intestinal fluids
    Siri, Cecilia
    Liu, Yang
    Masset, Thibault
    Dudefoi, William
    Oldham, Dean
    Minghetti, Matteo
    Grandjean, Dominique
    Breider, Florian
    ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS, 2021, 23 (10) : 1566 - 1577
  • [27] Degradation of functionalized porous silicon in simulated blood, gastric, and intestinal fluids.
    Thornberry, DR
    Fulmer, GR
    Rhodes, SD
    Porter, LA
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2005, 229 : U679 - U679
  • [28] Removal of tar model compounds produced from biomass gasification using activated carbons
    Biomass Technology Research Center, National Institute of Advanced Industrial Science and Technology , Suehiro 2-2-2, Hiro, Kure, Hiroshima 737-0197, Japan
    不详
    Nihon Enerugi Gakkaishi, 2007, 9 (707-711):
  • [29] Removal of a cationic bisbiguanide using Functionalized Activated Carbons (FACs)
    Banerjee, Debasree
    Sarkar, Ujjaini
    Chakraborty, Sayantani
    Roy, Debasri
    PROCESS SAFETY AND ENVIRONMENTAL PROTECTION, 2014, 92 (06) : 957 - 972
  • [30] Removal of Nickel(II) from Wastewater: Activated Carbons from Oilcakes
    Hema, M.
    Srinivasan, K.
    ASIAN JOURNAL OF CHEMISTRY, 2010, 22 (05) : 3675 - 3690
12345