Multi-scale modeling of soft fibrous tissues based on proteoglycan mechanics

被引：11

作者：

Linka, Kevin ^{[1
]}

Vu Ngoc Khiem ^{[1
]}

Itskov, Mikhail ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen, Dept Continuum Mech, Kackertstr 9, D-52072 Aachen, Germany

来源：

JOURNAL OF BIOMECHANICS | 2016年 / 49卷 / 12期

关键词：

Multi-scale modeling; Soft fibrous tissues; Proteoglycans; ATOMIC-FORCE MICROSCOPY; CONSTITUTIVE FRAMEWORK; COLLAGEN FIBRILS; ARTERIAL-WALLS; TENDON; MOLECULES; STRENGTH; DAMAGE; DNA; ELASTICITY;

D O I：

10.1016/j.jbiomech.2016.02.049

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Collagen in the form of fibers or fibrils is an essential source of strength and structural integrity in most organs of the human body. Recently, with the help of complex experimental setups, a paradigm change concerning the mechanical contribution of proteoglycans (PGs) took place. Accordingly, PG connections protect the surrounding collagen fibrils from over-stretching rather than transmitting load between them. In this paper, we describe the reported PG mechanics and incorporate it into a multi-scale model of soft fibrous tissues. To this end, a nano-to-micro model of a single collagen fiber is developed by taking the entropic-energetic transition on the collagen molecule level into account. The microscopic damage occurring inside the collagen fiber is elucidated by sliding of PGs as well as by over-stretched collagen molecules. Predictions of this two-constituent-damage model are compared to experimental data available in the literature. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：2349 / 2357

页数：9

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