Safety and immunogenicity of a live-attenuated auxotrophic candidate vaccine against the intracellular pathogen Rhodococcus equi

被引：33
|
作者：
Lopez, A. M. [1 ]
Townsend, H. G. G. [1 ,2 ]
Allen, A. L. [3 ]
Hondalus, M. K. [4 ]
机构：
[1] Univ Saskatchewan, Vaccine & Infect Dis Org, Saskatoon, SK S7N 5E3, Canada
[2] Univ Saskatchewan, Western Coll Vet Med, Dept Vet Microbiol, Saskatoon, SK S7N 5B4, Canada
[3] Univ Saskatchewan, Western Coll Vet Med, Dept Vet Pathol, Saskatoon, SK S7N 5B4, Canada
[4] Univ Georgia, Coll Vet Med, Dept Infect Dis, Athens, GA 30602 USA
来源：
VACCINE | 2008年 / 26卷 / 07期
关键词：
Rhodococcus equi; live vaccine; foals;
D O I：
10.1016/j.vaccine.2007.10.069
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Rhodococcus equi causes serious pneumonia in neonatal foals and is an opportunistic pathogen of people with compromised cellular immunity. No effective vaccine against R. equi disease in foals is available. We tested the safety and immunogenicity of a live, fully attenuated riboflavin auxotrophic candidate vaccine strain of R. equi (R. equi rib-). We demonstrated that R. equi rib- is immunogenic and capable of inducing IFN-gamma responses in immunocompetent BALB/c mice, yet it is safe even in an immunocompromised SCID mouse infection model.. Moreover, it protects immunocompetent mice against virulent R. equi challenge. In foals, R. equi rib- was likewise safe and stimulated serum R. equi-specific immune responses. A preliminary immunization strategy did not afford protection against virulent R. equi challenge and therefore, optimization of the vaccine formulation and or vaccination protocol will be necessary. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：998 / 1009
页数：12
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