Functionalized gold nanorods for nanomedicine: Past, present and future

被引：61

作者：

Zhou, Jie ^{[1
]}

Cao, Zhonglin ^{[1
]}

Panwar, Nishtha ^{[2
]}

Hu, Rui ^{[1
]}

Wang, Xiaomei ^{[3
]}

Qu, Junle ^{[1
]}

Tjin, Swee Chuan ^{[2
]}

Xu, Gaixia ^{[1
]}

Yong, Ken-Tye ^{[2
]}

机构：

[1] Shenzhen Univ, Coll Optoelect Engn, Key Lab Optoelect Devices & Syst, Minist Educ Guangdong Prov, Shenzhen 518060, Peoples R China

[2] Nanyang Technol Univ, Sch Elect & Elect Engn, Singapore 639798, Singapore

[3] Shenzhen Univ, Hlth Sci Ctr, Dept Physiol, Sch Basic Med Sci, Shenzhen 518060, Peoples R China

来源：

COORDINATION CHEMISTRY REVIEWS | 2017年 / 352卷

基金：

中国国家自然科学基金;

关键词：

Gold nanorods; Toxicity; In vivo; Drug delivery; Gene delivery; Therapeutic diagnostic; Imaging; Cancer therapy; SURFACE-PLASMON RESONANCE; ENHANCED RAMAN-SCATTERING; SEED-MEDIATED SYNTHESIS; SELF-ASSEMBLED MONOLAYERS; HIGH-YIELD SYNTHESIS; ASPECT-RATIO; PHOTOTHERMAL THERAPY; CANCER-THERAPY; DRUG-DELIVERY; SENSITIVE DETECTION;

D O I：

10.1016/j.ccr.2017.08.020

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Gold nanorods (GNRs) have been on the forefront in biophotonics due to their extremely attractive optical properties and their use in a variety of applications in biosensing and nanomedicine. In this review, we first present the synthesis and functionalization approaches and then describe the extraordinary optical properties of GNRs. Thereafter, we elaborate on the recent research advances in the use of GNRs for sensing, and highlight the increasing use of GNRs for in vitro and in vivo diagnostics and therapeutic applications. We also discuss the toxicity effects of GNRs on the body and environment and present an evaluation on the role of surface modifications in affecting the toxicity in biological systems. Finally, we provide concluding perspectives on the overall current status, challenges, and future directions for the use of GNRs in research and clinical applications. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：15 / 66

页数：52

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