Interleukin 6 gene polymorphism is associated with protein serum level and disease activity in Polish patients with rheumatoid arthritis

被引:10
|
作者
Wielinska, J. [1 ]
Dratwa, M. [1 ]
Swierkot, J. [2 ]
Korman, L. [2 ]
Iwaszko, M. [1 ]
Wysoczanska, B. [1 ]
Bogunia-Kubik, K. [1 ]
机构
[1] Polish Acad Sci, Hirszfeld Inst Immunol & Expt Therapy, Lab Clin Immunogenet & Pharmacogenet, R Weigla 12, PL-53114 Wroclaw, Poland
[2] Wroclaw Med Univ, Dept Rheumatol & Internal Med, Wroclaw, Poland
关键词
gene polymorphism; IL-6; rheumatoid arthritis; rs1800795; PROMOTER POLYMORPHISM; CLINICAL-SIGNIFICANCE; IL-6; GENE;
D O I
10.1111/tan.13355
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Interleukin 6 (IL-6) is a pro-inflammatory cytokine involved in the development of rheumatoid arthritis (RA). The present study aimed to determine the possible association of the IL6 (rs1800795, G > C) polymorphism with RA susceptibility, disease progression and protein serum levels. Distribution of IL6 alleles and genotypes was similar in RA patients and controls. As expected, patients before induction of anti-tumour necrosis factor agents had significantly higher IL-6 levels as compared with controls (P = 0.002). The CC homozygous patients were characterised with the highest average concentrations of this pro-inflammatory cytokine before treatment (P = 0.028), and they also more frequently presented with more active disease (P = 0.048). These results imply that the IL6 rs1800795 CC homozygosity may play a rather unfavourable role in RA.
引用
收藏
页码:38 / 41
页数:4
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