GLYT1 Inhibition Reduces Schizophrenia-like Symptoms Produced by Ketamine

被引:0
|
作者
Driesen, Naomi R. [1 ,2 ]
Ranganathan, Mohini [1 ,3 ]
DeMartinis, Nicholas [4 ]
Bloch, Michael [1 ]
Morgan, Peter T. [1 ]
Gueorguieva, Raitza [1 ,5 ]
Ahn, Kyungheup [1 ,3 ]
D'Souza, Deepak C. [1 ,3 ]
Krystal, John H. [1 ,3 ]
机构
[1] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA
[2] VA Connecticut Hlth Care Syst, Psychol, West Haven, CT USA
[3] VA Connecticut Hlth Care Syst, Psychiat, West Haven, CT USA
[4] Pfizer, Neurosci, Cambridge, MA USA
[5] Yale Univ, Sch Epidemiol & Publ Hlth, New Haven, CT USA
关键词
NMDA Receptor; Ketamine; Positive Symptoms; GlyT1; Inhibitor; Schizophrenia;
D O I
暂无
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
561
引用
收藏
页数:1
相关论文
共 50 条
  • [31] SCHIZOPHRENIA-LIKE SYMPTOMS, MESENCEPHALIC TUMOR WITH HYDROCEPHALUS, AND DOPAMINERGIC PHARMACOLOGY
    NEUMAN, E
    LECRUBIER, Y
    RANCUREL, G
    FOHANNO, D
    ALLILAIRE, JF
    SEMAINE DES HOPITAUX, 1993, 69 (38): : 1376 - 1383
  • [32] Anticipatory pleasure and approach motivation in schizophrenia-like negative symptoms
    Engel, Maike
    Fritzsche, Anja
    Lincoln, Tania M.
    PSYCHIATRY RESEARCH, 2013, 210 (02) : 422 - 426
  • [33] GRAY-MATTER DEFICITS IN EPILEPSY WITH SCHIZOPHRENIA-LIKE SYMPTOMS
    MARSH, L
    MATHALON, DH
    MORRELL, MJ
    PFEFFERBAUM, A
    BIOLOGICAL PSYCHIATRY, 1995, 37 (09) : 631 - 632
  • [34] A CASE OF KLINEFELTER SYNDROME WITH SCHIZOPHRENIA-LIKE SYMPTOMS AND MEDIASTINAL TUMOR
    TOYODA, K
    MOTOMURA, N
    SAKAI, T
    YASUDA, M
    TSUTSUMI, S
    JAPANESE JOURNAL OF HUMAN GENETICS, 1982, 27 (02): : 171 - 171
  • [35] CT SCAN EXAMINATION ON EPILEPTICS SHOWING SCHIZOPHRENIA-LIKE SYMPTOMS
    OANA, Y
    FOLIA PSYCHIATRICA ET NEUROLOGICA JAPONICA, 1978, 32 (03): : 399 - 400
  • [36] Discovery of AMG 747, a novel glycine transporter type-1 (GlyT1) inhibitor, as a potential treatment for negative, cognitive and positive symptoms of schizophrenia
    Qian, Wenyuan
    Amegadzie, Albert
    Chen, Jian
    Xia, Xiaoyang
    Chen, Hang
    Murphy, Odette
    Cueva, Madelyn
    Danao, Jean
    Ilch, Christopher
    Taborn, Kristin
    Rao, Sara
    Gavva, Narender
    Reid, Darren
    Hickman, Dean
    Hsieh, Faye
    Chen, Jiyun
    Kornecook, Tom
    Hungate, Randall
    Treanor, James
    Allen, Jennifer
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2013, 246
  • [37] Isoquinucline-based GlyT1 inhibitors for schizophrenia: Discovery, optimization, synthesis, and in vivo pharmacology
    Albert, Jeffrey S.
    Alhambra, Cristobal
    Brott, David
    Brugel, Todd
    Chopra, Maninder
    Ernst, Glen E.
    Forst, Janet
    Gharahdaghi, Farzin
    Gryte, David
    Gupta, Anshul
    Holmquist, Christopher
    Jonak, Jerry
    Koether, Gerard
    Liu, Jay
    Milano, Joseph
    Norris, Tyrell E.
    Potts, William M.
    Smaggin, Gennady
    Song, Dekun
    Sydserff, Simon
    Sylvester, Mark
    Tian, Gaochao
    Varnes, Jeffrey G.
    Veale, Chris A.
    Wang, Xia
    Widzowski, Dan
    Wilkins, Dee
    Wood, Michael
    Xiong, Hui
    Zukin, Steven
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2010, 240
  • [38] Isoquinucline-based GlyT1 inhibitors for schizophrenia: Discovery, optimization, synthesis, and in vivo pharmacology
    Albert, Jeffrey S.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012, 243
  • [39] Familial aggregation of schizophrenia-like symptoms in Huntington's disease
    Tsuang, D
    DiGiacomo, L
    Lipe, H
    Bird, TD
    AMERICAN JOURNAL OF MEDICAL GENETICS, 1998, 81 (04): : 323 - 327
  • [40] GLYCINE TRANSPORTER TYPE 1 (GLYT1) INHIBITOR RG1678: RESULTS OF THE PROOF-OF-CONCEPT STUDY FOR THE TREATMENT OF NEGATIVE SYMPTOMS IN SCHIZOPHRENIA
    Umbricht, Daniel
    Martin-Facklam, M.
    Pizzagalli, F.
    Youssef, E.
    Yoo, K.
    Dorflinger, E.
    Bausch, A.
    Arrowsmith, R.
    Alberati, D.
    Santarelli, L.
    SCHIZOPHRENIA BULLETIN, 2011, 37 : 324 - 324