Ameliorative effect of Rutin on sodium fluoride-induced hypertension through modulation of Kim-1/NF-κB/Nrf2 signaling pathway in rats

被引：25

作者：

Oyagbemi, Ademola Adetokunbo ^{[1
]}

Omobowale, Temidayo Olutayo ^{[2
]}

Ola-Davies, Olufunke Eunice ^{[1
]}

Asenuga, Ebunoluwa Racheal ^{[3
]}

Ajibade, Temitayo Olabisi ^{[1
]}

Adejumobi, Olumuyiwa Abiola ^{[2
]}

Afolabi, Jeremiah Moyinoluwa ^{[2
]}

Ogunpolu, Blessing Seun ^{[2
]}

Falayi, Olufunke Olubunmi ^{[4
]}

Ayodeji, Fatimah ^{[1
]}

Hassan, Fasilat Oluwakemi ^{[1
]}

Saba, Adebowale Bernard ^{[4
]}

Adedapo, Adeolu Alex ^{[4
]}

Yakubu, Momoh Audu ^{[5
]}

机构：

[1] Univ Ibadan, Dept Vet Physiol & Biochem, Fac Vet Med, Ibadan, Nigeria

[2] Univ Ibadan, Dept Vet Med, Fac Vet Med, Ibadan, Nigeria

[3] Univ Benin, Dept Vet Physiol & Biochem, Fac Vet Med, Benin, Nigeria

[4] Univ Ibadan, Dept Vet Pharmacol & Toxicol, Fac Vet Med, Ibadan, Nigeria

[5] Texas Southern Univ, Dept Environm & Interdisciplinary Sci, Coll Sci Engn & Technol, Vasc Biol Unit,Ctr Cardiovasc Dis COPHS, Houston, TX USA

来源：

ENVIRONMENTAL TOXICOLOGY | 2018年 / 33卷 / 12期

基金：

新加坡国家研究基金会;

关键词：

antioxidant; hypertension; oxidative stress; Rutin; sodium fluoride; NF-KAPPA-B; OXIDATIVE STRESS; XANTHINE-OXIDASE; KIDNEY INJURY; NITRIC-OXIDE; INDUCED NEPHROTOXICITY; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; TNF-ALPHA; INFLAMMATION;

D O I：

10.1002/tox.22636

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Sodium fluoride is one of the neglected environmental contaminants. Inorganic fluorides in the environment are found in the air, water, and land. In the study, forty-male Wistar albino rats were randomly divided into four groups with 10 rats in a group. Group A was the control group which was given normal saline, Group B was exposed to 300 ppm of NaF in drinking water, while Groups C and D received NaF along Rutin (100 mg/kg and 200 mg/kg) orally daily for a week. Administration of NaF alone led to significant increases in blood pressure, and deceased serum nitric oxide. Immunohistochemistry revealed higher expressions of kidney injury molecule I (Kim-1), nuclear factor kappa beta (NF-kappa B), and down regulation of nuclear factor erythroid 2-related factor 2 (Nrf2) in rats administered NaF. Rutin co-treatment with NaF normalized blood pressure, lowered Kim-1 and NF-kappa B expressions, and improved nitric oxide bioavailability.

引用

页码：1284 / 1297

页数：14

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