One-pot synthesis of substituted indolines via a copper-catalyzed sequential multicomponent/C-N coupling reaction

被引：19
|
作者：
Jin, Hongwei [1 ,2 ]
Zhou, Bingwei [2 ]
Wu, Zhi [2 ]
Shen, Yang [1 ]
Wang, Yanguang [1 ]
机构：
[1] Zhejiang Univ, Dept Chem, Hangzhou 310027, Peoples R China
[2] Zhejiang Univ Technol, Coll Chem Engn & Mat Sci, Hangzhou 310014, Zhejiang, Peoples R China
来源：
TETRAHEDRON | 2011年 / 67卷 / 06期
基金：
中国国家自然科学基金;
关键词：
Indolines; Copper; Multicomponent reactions; C-N coupling; Cascade reactions; SPIROOXINDOLE NATURAL-PRODUCTS; FACILE ACCESS; C-N; ASYMMETRIC HYDROGENATION; EFFICIENT SYNTHESIS; AMIDE SYNTHESIS; SULFONYL AZIDE; ARYL; ARYLATION; ALKYNES;
D O I：
10.1016/j.tet.2010.11.094
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
One-pot synthesis of 2-(N-sulfonylimino)indolines has been developed. The procedure combines the copper-catalyzed three-component reaction of sulfonyl azides, o-bromophenylacetylenes, and amines and the copper-catalyzed intramolecular C-N coupling in one sequence, which afforded the products in moderate to good yields. The resulting 2-(N-sulfonylimino)indolines could be easily transformed to pharmaceutically valuable oxindoles (indolin-2-ones). (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1178 / 1182
页数：5
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