Copper-Catalyzed Synthesis of Aryl Thioamides from Aryl Aldehydes and Tetramethylthiuram Disulfide

被引：21

作者：

Zeng, Meng-Tian ^{[1
]}

Wang, Min ^{[1
]}

Peng, Han-Ying ^{[1
]}

Cheng, Yu ^{[1
]}

Dong, Zhi-Bing ^{[1
]}

机构：

[1] Wuhan Inst Technol, Sch Chem & Environm Engn, Wuhan 430205, Hubei, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2018年 / 50卷 / 03期

基金：

中国国家自然科学基金;

关键词：

aryl thioamide; benzaldehyde; tetramethylthiuram disulfide; copper; di-tert-butyl peroxide; CARBOXYLIC-ACIDS; THIONATION; AMIDATION; AMIDES; SULFUR;

D O I：

10.1055/s-0036-1590936

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel and convenient method for the synthesis of aryl thioamides from aryl aldehydes and tetramethylthiuram disulfide (TMTD) without the use of sulfurating reagent was explored. In the presence of CuI and di-tert-butyl peroxide (DTBP), various aryl thioamides were prepared with good to excellent yields, tetramethylthiuram disulfide as thioamide source is essential for this transformation. The protocol features broad substrate scope, nice yields, operability and commercially available and inexpensive raw materials, showing its practical synthetic value in organic synthesis.

引用

页码：644 / 650

页数：7

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