L-DOPA does not facilitate nitric oxide production in the rat striatum and substantia nigra: In vivo microdialysis study

被引：7

作者：

Kashihara, K ^{[1
]}

Sakai, K ^{[1
]}

Marui, K ^{[1
]}

Shohmori, T ^{[1
]}

机构：

[1] Okayama Univ, Sch Med, Dept Neurol, Okayama 7000914, Japan

来源：

LIFE SCIENCES | 1998年 / 63卷 / 04期

关键词：

L-dopa; microdialysis; nitric oxide; striatum; substantia nigra;

D O I：

10.1016/S0024-3205(98)00275-6

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Using in vivo microdialysis and flow-injection, we evaluated the production of nitric oxide (NO) in the striatum and substantia nigra of freely moving rats in response to challenge doses of L-dihydroxyphenylalanine (L-DOPA) by measuring the NO metabolite levels of nitrate and nitrite. The dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) concentrations also were determined in the same perfusates. Intraperitoneal injection of L-DOPA produced a significant, dose-dependent increase in the extracellular levels of dopamine and DOPAC in these areas, but did not modify the extracellular levels of the NO metabolites. An acute dose of L-DOPA does not appear to facilitate NO production in the rat striatum and substantia nigra. (C) 1998 Elsevier Science Inc.

引用

页码：PL59 / PL64

页数：6

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