L-DOPA does not facilitate nitric oxide production in the rat striatum and substantia nigra: In vivo microdialysis study

被引：7
|
作者：
Kashihara, K [1 ]
Sakai, K [1 ]
Marui, K [1 ]
Shohmori, T [1 ]
机构：
[1] Okayama Univ, Sch Med, Dept Neurol, Okayama 7000914, Japan
来源：
LIFE SCIENCES | 1998年 / 63卷 / 04期
关键词：
L-dopa; microdialysis; nitric oxide; striatum; substantia nigra;
D O I：
10.1016/S0024-3205(98)00275-6
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Using in vivo microdialysis and flow-injection, we evaluated the production of nitric oxide (NO) in the striatum and substantia nigra of freely moving rats in response to challenge doses of L-dihydroxyphenylalanine (L-DOPA) by measuring the NO metabolite levels of nitrate and nitrite. The dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) concentrations also were determined in the same perfusates. Intraperitoneal injection of L-DOPA produced a significant, dose-dependent increase in the extracellular levels of dopamine and DOPAC in these areas, but did not modify the extracellular levels of the NO metabolites. An acute dose of L-DOPA does not appear to facilitate NO production in the rat striatum and substantia nigra. (C) 1998 Elsevier Science Inc.
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收藏
页码：PL59 / PL64
页数：6
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