The novel TrkB receptor agonist 7,8-dihydroxyflavone enhances neuromuscular transmission

被引：38
|
作者：
Mantilla, Carlos B. [1 ,2 ]
Ermilov, Leonid G. [2 ]
机构：
[1] Mayo Clin, Coll Med, Dept Anesthesiol, Rochester, MN 55905 USA
[2] Mayo Clin, Coll Med, Dept Physiol & Biomed Engn, Rochester, MN 55905 USA
来源：
MUSCLE & NERVE | 2012年 / 45卷 / 02期
关键词：
flavones; muscle fatigue; neuromuscular transmission failure; neurotrophins; synaptic efficacy; RAT DIAPHRAGM; BDNF; NEUROTROPHIN-4; POTENTIATION; SYNAPSES; RELEASE; MUSCLE; TRIAL; ALS;
D O I：
10.1002/mus.22295
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Neurotrophin signaling at the neuromuscular junction modulates cholinergic transmission and enhances neuromuscular transmission via the tropomyosin-related kinase receptor subtype B (TrkB).A novel flavonoid, 7,8-dihydroxyflavone (7,8-DHF), selectively activates TrkB receptors. Using TrkBF616A mice that are susceptible to specific inhibition of TrkB activity by 1NMPP1, we show that neuromuscular transmission is enhanced by 7,8-DHF (?32%) via activation of TrkB in diaphragm muscle. The small molecule 7,8-DHF may constitute a novel therapy to improve neuromuscular function. Muscle Nerve, 2012
引用
收藏
页码：274 / 276
页数：3
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