The novel TrkB receptor agonist 7,8-dihydroxyflavone enhances neuromuscular transmission

被引：38

作者：

Mantilla, Carlos B. ^{[1
,2
]}

Ermilov, Leonid G. ^{[2
]}

机构：

[1] Mayo Clin, Coll Med, Dept Anesthesiol, Rochester, MN 55905 USA

[2] Mayo Clin, Coll Med, Dept Physiol & Biomed Engn, Rochester, MN 55905 USA

来源：

MUSCLE & NERVE | 2012年 / 45卷 / 02期

关键词：

flavones; muscle fatigue; neuromuscular transmission failure; neurotrophins; synaptic efficacy; RAT DIAPHRAGM; BDNF; NEUROTROPHIN-4; POTENTIATION; SYNAPSES; RELEASE; MUSCLE; TRIAL; ALS;

D O I：

10.1002/mus.22295

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Neurotrophin signaling at the neuromuscular junction modulates cholinergic transmission and enhances neuromuscular transmission via the tropomyosin-related kinase receptor subtype B (TrkB).A novel flavonoid, 7,8-dihydroxyflavone (7,8-DHF), selectively activates TrkB receptors. Using TrkBF616A mice that are susceptible to specific inhibition of TrkB activity by 1NMPP1, we show that neuromuscular transmission is enhanced by 7,8-DHF (?32%) via activation of TrkB in diaphragm muscle. The small molecule 7,8-DHF may constitute a novel therapy to improve neuromuscular function. Muscle Nerve, 2012

引用

页码：274 / 276

页数：3

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