Synthesis of novel spiropyrrolizidines as potent antimicrobial agents for human and plant pathogens

被引：115
|
作者：
Periyasami, Govindasami [1 ]
Raghunathan, Raghavachary [1 ]
Surendiran, Gangadharan [2 ]
Mathivanan, Narayanasamy [2 ]
机构：
[1] Univ Madras, Dept Organ Chem, Madras 600025, Tamil Nadu, India
[2] Univ Madras, Ctr Adv Studies Bot, Madras 600025, Tamil Nadu, India
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 07期
关键词：
1,3-dipolar cycloaddition; azomethine ylide; microwave; pyrrolizidine;
D O I：
10.1016/j.bmcl.2008.02.065
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of novel dispirooxindolopyrrolizidine derivatives have been synthesized through 1,3-dipolar cycloaddition reaction of azomethine ylide generated from proline and isatin with the dipolarophile (E)-2-arylidine-1-keto carbazoles. The synthesized cycloadducts were evaluated for antimicrobial activities. Compounds 7d and 7e showed relatively good antibacterial and antifungal activities. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2342 / 2345
页数：4
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