One-Pot Reductive Acetylation of Aldehydes using 1-Hydrosilatrane in Acetic Acid

被引：5

作者：

James, Reuben R. ^{[1
]}

Herlugson, Sharon ^{[1
]}

Varjosaari, Sami E. ^{[1
]}

Skrypai, Vladislav ^{[1
]}

Shakeel, Zainab ^{[2
]}

Gilbert, Thomas M. ^{[1
]}

Adler, Marc J. ^{[1
,2
]}

机构：

[1] Northern Illinois Univ, Dept Chem & Biochem, 1425 W Lincoln Hwy, De Kalb, IL 60115 USA

[2] Ryerson Univ, Dept Biol & Chem, 350 Victoria St, Toronto, ON M5B 2K3, Canada

来源：

SYNOPEN | 2019年 / 3卷 / 01期

关键词：

esterification; reduction; silatrane; one-pot synthesis; CARBONYL-COMPOUNDS; DEACETYLATION; ACETATES; KETONES;

D O I：

10.1055/s-0037-1611697

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A one-pot, direct reductive acetylation of aldehydes was achieved under mild conditions using 1-hydrosilatrane as a safe and easily accessible catalyst. Described herein is a facile synthesis that produces acylated primary alcohols that can serve as valuable building blocks for organic synthesis. The method has good functional group tolerance and works for a range of aryl aldehydes, with the notable exception of electron-rich arenes. A library of esters was isolated by flash chromatography in yields as high as 92%.

引用

页码：1 / 3

页数：3

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