Biotransformation of adrenosterone by filamentous fungus, Cunninghamella elegans

被引：47
|
作者：
Choudhary, Muhammad Iqbal [1 ]
Khan, Naik T. [1 ]
Musharraf, Syed G. [1 ]
Anjum, Shazia [1 ]
Atta-ur-Rahman [1 ]
机构：
[1] Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan
来源：
STEROIDS | 2007年 / 72卷 / 14期
关键词：
adrenosterone microbial transformation; Cunninghamella elegans; hydroxylation;
D O I：
10.1016/j.steroids.2007.08.002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Microbial transformation of adrenosterone (1) by suspended-cell cultures of the filamentous fungus Cunninghamella elegans resulted in the production of five metabolites 2-6, which were identified as 9 alpha-hydroxyadrenosterone (2), 11-ketotestosterone (3), 6 beta-hydroxyadrenosterone (4), 9 alpha-hydroxy-11-ketotestosterone (5), and 6 beta-hydroxy-11-ketotestosterone (6). Structures of new metabolites 2, 5, and 6 were established by single-crystal X-ray diffraction analysis.
引用
收藏
页码：923 / 929
页数：7
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