Nonsystemic amplification of MYC with CDK4 and MDM2 in a malignant mixed tumor of salivary gland

被引：30
|
作者：
Rao, PH
Murty, VVVS
Louie, DC
Chaganti, RSK
机构：
[1] Mem Sloan Kettering Canc Ctr, Cell Biol & Genet Program, New York, NY 10021 USA
[2] Mem Sloan Kettering Canc Ctr, Dept Human Genet, New York, NY 10021 USA
[3] Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USA
[4] Coll Phys & Surg, Dept Pathol, New York, NY USA
来源：
CANCER GENETICS AND CYTOGENETICS | 1998年 / 105卷 / 02期
关键词：
D O I：
10.1016/S0165-4608(98)00013-2
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Karyotypic analysis of a metastatic malignant mixed tumor of the salivary gland revealed the presence of double minute chromosomes (dmin), indicative of gene amplification. Comparative genomic hybridization analysis of DNA extracted from the primary and a renal metastasis indicated overt amplification of DNA sequences derived from 8q23-24 and 12q13-15 regions. Subsequent Southern blot analysis of tumor DNA from the metastasis with the use of probes previously mapped to those regions indicated amplification of MYC at 8q23-24 and CDK4 and MDM2 at 12q13-15. Fluorescence in situ hybridization of differentially labeled MYC and MDM2 genes hybridized to tumor metaphase chromosomes revealed an independent nonsyntenic amplification of MYC and MDM2 on dmin in this tumor. (C) Elsevier Science Inc., 1998
引用
收藏
页码：160 / 163
页数：4
相关论文
共 50 条
  • [21] Gnathic giant-cell-rich conventional osteosarcoma with MDM2 and CDK4 gene amplification
    Hirose, Katsutoshi
    Okura, Masaya
    Sato, Sunao
    Murakami, Shumei
    Ikeda, Jyun-Ichiro
    Noda, Yuri
    Fukuda, Yasuo
    Morii, Eiichi
    Toyosawa, Satoru
    HISTOPATHOLOGY, 2017, 70 (07) : 1171 - 1173
  • [22] The Utility of MDM2 and CDK4 Staining in Head and Neck Osteosarcoma
    Limbach, Abberly Lott
    Mostofi, Reza
    Lingen, Mark
    Cipriani, Nicole
    LABORATORY INVESTIGATION, 2015, 95 : 327A - 327A
  • [23] COAMPLIFICATION OF THE CDK4 GENE WITH MDM2 AND GLI IN HUMAN SARCOMAS
    KHATIB, ZA
    MATSUSHIME, H
    VALENTINE, M
    SHAPIRO, DN
    SHERR, CJ
    LOOK, AT
    CANCER RESEARCH, 1993, 53 (22) : 5535 - 5541
  • [24] Reproducibility of MDM2 and CDK4 staining in soft tissue tumors
    Binh, MBN
    Garau, XS
    Guillou, L
    Aurias, A
    Coindre, JM
    AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2006, 125 (05) : 693 - 697
  • [25] The Utility of MDM2 and CDK4 Staining in Head and Neck Osteosarcoma
    Limbach, Abberly Lott
    Mostofi, Reza
    Lingen, Mark
    Cipriani, Nicole
    MODERN PATHOLOGY, 2015, 28 : 327A - 327A
  • [26] Combined targeting of MDM2 and CDK4 is synergistic in dedifferentiated liposarcomas
    Laroche-Clary, Audrey
    Chaire, Vanessa
    Algeo, Marie-Paule
    Derieppe, Marie-Alix
    Loarer, Francois L.
    Italiano, Antoine
    JOURNAL OF HEMATOLOGY & ONCOLOGY, 2017, 10
  • [27] Combined targeting of MDM2 and CDK4 is synergistic in dedifferentiated liposarcomas
    Audrey Laroche-Clary
    Vanessa Chaire
    Marie-Paule Algeo
    Marie-Alix Derieppe
    François L. Loarer
    Antoine Italiano
    Journal of Hematology & Oncology, 10
  • [28] Investigating the effect of CDK4/6 and MDM2 inhibition on melanoma
    Slesur, Lauren
    Vilgelm, Anna
    Al-Rohil, Rami
    Richmond, Ann
    MOLECULAR CANCER THERAPEUTICS, 2018, 17 (01)
  • [29] Expression of MDM2 and CDK4 in liposarcoma arising in malignant phyllodes tumour-a case report
    Narasimhamurthy, M.
    VIRCHOWS ARCHIV, 2016, 469 : S64 - S64
  • [30] Co-amplification and overexpression of CDK4, SAS and MDM2 occurs frequently in human parosteal osteosarcomas
    Wunder, JS
    Eppert, K
    Burrow, SR
    Gogkoz, N
    Bell, RS
    Andrulis, IL
    ONCOGENE, 1999, 18 (03) : 783 - 788
12345