Autochthonous acute hepatitis E: treatment with sofosbuvir and ribavirin

被引：22

作者：

Biliotti, Elisa ^{[1
]}

Franchi, Cristiana ^{[1
]}

Spaziante, Martina ^{[1
]}

Garbuglia, Anna Rosa ^{[2
]}

Volpicelli, Lorenzo ^{[1
]}

Palazzo, Donatella ^{[1
]}

De Angelis, Maurizio ^{[1
]}

Esvan, Rozenn ^{[1
]}

Taliani, Gloria ^{[1
]}

机构：

[1] Sapienza Univ Rome, Clin Trop Med, Dept Clin Med, Rome, Italy

[2] Natl Inst Infect Dis Lazzaro Spallanzani, Lab Virol, Rome, Italy

来源：

INFECTION | 2018年 / 46卷 / 05期

关键词：

Hepatitis E; Ribavirin; Sofosbuvir; Acute-on-chronic-liver-failure; Hepatitis C; E VIRUS-INFECTION; PATIENT;

D O I：

10.1007/s15010-018-1168-7

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

IntroductionHepatitis E virus (HEV) is an emerging cause of autochthonous-acute-hepatitis and acute-on-chronic-liver-failure in western countries. Treatment is not routinely used, despite ribavirin has a good antiviral effect. In vitro sofosbuvir inhibits HEV replication, but clinical data are lacking.Case reportWe report a case of acute-on-chronic-liver-failure due to HEV treated with sofosbuvir and ribavirin. Thetreatment was capable of rapidly inducing both HCV and HEV viral suppression.ConclusionIn conclusion, although more data are required before firm conclusions could be drawn, the combination of sofosbuvir and ribavirin in not immunosuppressed patients with acute hepatitis E may be able to clear HEV infection.

引用

页码：725 / 727

页数：3

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