Synthesis of 5-(trifluoromethyl)cyclohexane-1,3-dione and 3-amino-5-(trifluoromethyl)cyclohex-2-en-1-one: new trifluoromethyl building block

被引：15
|
作者：
Fadeyi, Olugbeminiyi O. [1 ]
Okoro, Cosmas O. [1 ]
机构：
[1] Tennessee State Univ, Dept Chem, Nashville, TN 37209 USA
来源：
TETRAHEDRON LETTERS | 2008年 / 49卷 / 32期
关键词：
trifluoromethyl; cyclohexane-1,3-dione; dianion; by-product; diester;
D O I：
10.1016/j.tetlet.2008.05.120
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple synthesis of 5-(trifluoromethyl)cyclohexane-1,3-dione and 3-amino-5-(trifluoromethyl)cyclohex-2-en-1-one from the sodium salt of methyl or ethyl-4-hydroxy-2-oxo-6-(trifluoromethyl)cyclohex-3-en-1-oate is demonstrated. The compounds represent highly functionalized reactive intermediates for the synthesis of organic and heterocyclic compounds containing a trifluoromethyl group. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4725 / 4727
页数：3
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