Synthesis of 5-(trifluoromethyl)cyclohexane-1,2,3-trione (cVTC): new trifluoromethyl building block

被引：3

作者：

Obi, Chibuike D. ^{[1
]}

Okoro, Cosmas O. ^{[1
]}

机构：

[1] Tennessee State Univ, Dept Chem, 3500 John A Merritt Blvd, Nashville, TN 37209 USA

来源：

TETRAHEDRON LETTERS | 2016年 / 57卷 / 47期

关键词：

Trifluoromethyl; Vicinal tricarbonyl; Cycloalkanone; Fluorinated Cyclohexane-1,2-3-trione; Triketone; VICINAL TRICARBONYLS; 1,3-DICARBONYL COMPOUNDS; CHEMISTRY;

D O I：

10.1016/j.tetlet.2016.10.043

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple synthesis of 5-(trifluoromethyl)cyclohexane-1,2,3-trione is demonstrated in one step, by reacting 5-(trifluoromethyl)cyclohexane-1,3-dione with cerium(IV)ammonium nitrate (CAN) in methanol. The compound represents a highly functionalized oxygen-rich reactive intermediate for the synthesis of organic and heterocyclic compounds containing fluorine. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：5259 / 5261

页数：3

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