Fetal surgery for myelomeningocele: trials and tribulations

被引：50
|
作者：
Adzick, N. Scott [1 ]
机构：
[1] Univ Penn, Childrens Hosp Philadelphia, Sch Med, Ctr Fetal Diag & Treatment, Philadelphia, PA 19104 USA
来源：
JOURNAL OF PEDIATRIC SURGERY | 2012年 / 47卷 / 02期
基金：
美国国家卫生研究院;
关键词：
Myelomeningocele; Spina bifida; Hydrocephalus; Hindbrain herniation; Prenatal diagnosis; Fetal surgery; Management of Myelomeningocele Study (MOMS); NEURAL-TUBE DEFECTS; IN-UTERO REPAIR; SPINAL-CORD; HINDBRAIN HERNIATION; NEUROLOGICAL FUNCTION; PRENATAL-DIAGNOSIS; HUMAN FETUSES; BIFIDA; PREVALENCE; BIRTH;
D O I：
10.1016/j.jpedsurg.2011.11.021
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
The rationale for in utero repair of myelomeningocele (MMC) in the context of pathologic observations, animal models, and outcomes from the initial experience with human fetal MMC repair is presented. This has now culminated in a randomized trial, Management of Myelomeningocele Study, the findings of which are listed. The story is focused on the milestone contributions of members of the Center for Fetal Diagnosis and Treatment at the Children's Hospital of Philadelphia on the road to successful fetal surgery for spina bifida. This is now performed in selected patients and presents an additional therapeutic alternative for expectant mothers carrying a fetus with MMC. (C) 2012 Elsevier Inc. All rights reserved.
引用
收藏
页码：273 / 281
页数：9
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