Stereoselective Transformation of Chiral Amine: Novel Approach to the Synthesis of Optically Active Intermediate of Silodosin

被引：0

作者：

Reddy, R. Buchi ^{[1
]}

More, Kishor R. ^{[1
]}

Gupta, Leena ^{[1
]}

机构：

[1] Ipca Labs Ltd, Chem Res Div, Kandivali Ind Estate, Bombay 400067, Maharashtra, India

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2017年 / 51卷 / 06期

关键词：

silodosin; chiral amines; synthesis; stereoselective inversion; BENIGN PROSTATIC HYPERPLASIA; SYMPTOMS;

D O I：

10.1007/s11094-017-1641-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel, economical and highly efficient synthetic approach has been developed for the synthesis of silodosin optically active intermediate and its application to facile preparation of silodosin parent compound. It involves stereoselective inversion of unwanted isomer of the silodosin key chiral amine intermediate via the nucleophilic substitution reaction with azide ion on (a) N,N-ditosylimide derivative and (b) 2,4,6-triphenyl pyridinium cation.

引用

页码：494 / 499

页数：6

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