Ultrasound enhanced antitumor activity of liposomal doxorubicin in mice

被引：31

作者：

Hagtvet, Eirik ^{[2
,3
]}

Evjen, Tove J. ^{[4
,5
]}

Olsen, Dag Rune ^{[1
]}

Fossheim, Sigrid L. ^{[4
]}

Nilssen, Esben A.

机构：

[1] Univ Bergen, Fac Math & Nat Sci, N-5020 Bergen, Norway

[2] Oslo Univ Hosp, Inst Canc Res, Dept Radiat Biol, Oslo, Norway

[3] Univ Oslo, Oslo, Norway

[4] Epitarget AS, Oslo, Norway

[5] Univ Tromso, Fac Hlth Sci, Dept Pharm, Drug Transport & Delivery Grp, Tromso, Norway

来源：

JOURNAL OF DRUG TARGETING | 2011年 / 19卷 / 08期

关键词：

Therapeutic effect; low frequency ultrasound; drug delivery; drug release; STERICALLY STABILIZED LIPOSOMES; DRUG-DELIVERY; CARDIAC SAFETY; PHARMACOKINETICS; RELEASE; THRESHOLDS; TOXICITY;

D O I：

10.3109/1061186X.2010.551401

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Liposomal encapsulation of doxorubicin (DXR) improves tumor accumulation and reduces adverse effects. One possible strategy for further optimization of this delivery technology would be to design the liposome carrier to release its content within the tumor tissue in response to specific stimuli such as ultrasound (US). In this study, the tumor uptake properties and therapeutic efficacy of 1,2 distearoyl-sn-glycero-3-phosphatidylethanolamine-based liposomes containing DXR were investigated in nude mice bearing tumor xenografts. The liposomal DXR formulation alone showed no inhibitory effect on tumor growth. However, upon exposure to low frequency US in situ inhibition of tumor growth was demonstrated.

引用

页码：701 / 708

页数：8

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