Phytotoxicity and cytotoxicity of the fumonisin C and P series of mycotoxins from Fusarium spp. Fungi

被引：30

作者：

Abbas, HK ^{[1
]}

Shier, WT

Seo, JA

Lee, YW

Musser, SM

机构：

[1] ARS, USDA, So Weed Res Unit, Stoneville, MS 38776 USA

[2] Univ Minnesota, Dept Med Chem, Minneapolis, MN 55455 USA

[3] Seoul Natl Univ, Dept Agr Biol, Coll Agr & Life Sci, Suwon 441744, South Korea

[4] Seoul Natl Univ, Res Ctr New Biomat Agr, Coll Agr & Life Sci, Suwon 441744, South Korea

[5] US FDA, Ctr Food Safety & Appl Nutr, Washington, DC 20204 USA

来源：

TOXICON | 1998年 / 36卷 / 12期

关键词：

D O I：

10.1016/S0041-0101(98)00115-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Fumonisin C (FC) and P (FP) are two recently identified series of sphingosine-analog mycotoxins, for which biological activities have not previously been reported. FC1, FC2 and OH-FC1 (1 mu M) exhibited strong phytotoxicity comparable to the standard FBI in duckweed (Lemna pausicotata L.) cultures, whereas FC3 and FC4 were moderately phytotoxic. Conversely, FP1 exhibited weak phytotoxicity only at higher concentrations (greater than or equal to 10 mu M). These mycotoxins exhibited a similar pattern of cytotoxicity with FBI-sensitive cultured mammalian cell lines, H4TG and MDCK. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：2033 / 2037

页数：5

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