Microfluidic technologies in drug discovery

被引:75
|
作者
Pihl, J
Karlsson, M
Chiu, DT
机构
[1] Cellectricon AB, SE-41250 Gothenburg, Sweden
[2] Univ Washington, Dept Chem, Seattle, WA 98195 USA
关键词
D O I
10.1016/S1359-6446(05)03571-3
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Microfluidic systems are increasingly used as tools in various stages of the drug discovery process. Microscale systems offer several obvious advantages, such as low sample consumption and significantly reduced analysis or experiment time. These technologies raise the possibility of massive parallelization and concomitant reduction in cost per acquired data point. In addition, fluids in confined spaces display unique behaviors that can be used to acquire information not accessible using macroscopic systems. This article will focus on the implementation of microfluidic systems and technologies in the process of drug discovery.
引用
收藏
页码:1377 / 1383
页数:7
相关论文
共 50 条
  • [41] Company technologies demonstrates how drug discovery enhances drug design
    Dutton, G
    [J]. GENETIC ENGINEERING NEWS, 1997, 17 (17): : 17 - &
  • [42] Drug discovery strategies: Technologies to accelerate translation from target to drug
    Workman, P
    [J]. JOURNAL OF CHEMOTHERAPY, 2004, 16 : 13 - 15
  • [43] The Convergence of Stem Cell Technologies and Phenotypic Drug Discovery
    Friese, Alexandra
    Ursu, Andrei
    Hochheimer, Andreas
    Schoeler, Hans R.
    Waldmann, Herbert
    Bruder, Jan M.
    [J]. CELL CHEMICAL BIOLOGY, 2019, 26 (08): : 1050 - 1066
  • [44] Advances in luminescence-based technologies for drug discovery
    Baljinnyam, Bolormaa
    Ronzetti, Michael
    Simeonov, Anton
    [J]. EXPERT OPINION ON DRUG DISCOVERY, 2023, 18 (01) : 25 - 35
  • [45] RNA silencing technologies in drug discovery and target validation
    Rayburn, E
    Wang, H
    He, J
    Zhang, RW
    [J]. LETTERS IN DRUG DESIGN & DISCOVERY, 2005, 2 (01) : 1 - 18
  • [46] Natural products drug discovery - New technologies and approaches
    Stead, P
    [J]. DRUG DISCOVERY TODAY, 1997, 2 (07) : 256 - 259
  • [47] Human Embryonic Stem Cell Technologies and Drug Discovery
    Jensen, Janne
    Hyllner, Johan
    Bjorquist, Petter
    [J]. JOURNAL OF CELLULAR PHYSIOLOGY, 2009, 219 (03) : 513 - 519
  • [48] Drug discovery using grid technologies and DrugML.
    Hamada, M
    Inagaki, Y
    Goto, H
    Tanaka, S
    Chuman, H
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2004, 227 : U685 - U685
  • [49] The latest automated docking technologies for novel drug discovery
    Caballero, Julio
    [J]. EXPERT OPINION ON DRUG DISCOVERY, 2021, 16 (06) : 625 - 645
  • [50] Genetic information, genomic technologies, and the future of drug discovery
    Bumol, TF
    Watanabe, AM
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 285 (05): : 551 - 555