Synthesis of Isoquinolines from α-Aryl Vinyl Azides and Internal Alkynes by Rh-Cu Bimetallic Cooperation

被引：274

作者：

Wang, Yi-Feng ^{[1
]}

Toh, Kah Kah ^{[1
]}

Lee, Jian-Yuan ^{[1
]}

Chiba, Shunsuke ^{[1
]}

机构：

[1] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 26期

关键词：

alkynes; azides; copper; heterocycles; rhodium; CATALYZED OXIDATIVE COUPLING/CYCLIZATION; FREE-RADICAL REACTIONS; BOND FORMATION; CARBON-HYDROGEN; FUNCTIONALIZATION; BENZAMIDES; COMPLEXES; PYRROLES; IMINES; RU;

D O I：

10.1002/anie.201101009

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Catalysts in a relay: A synthetic method for delivering highly substituted isoquinolines has been developed (see scheme; Cp =C5Me5, DMF=N,N-dimethylformamide, TEMPO=2,2,6,6-tetramethylpiperidine-1-oxyl). A preliminary mechanistic study showed that the rhodium and copper cooperate synergistically in the multistep sequence. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：5927 / 5931

页数：5