Muscarinic acetylcholine receptors as CNS drug targets

被引：328
|
作者：
Langmead, Christopher J. [1 ]
Watson, Jeannette [1 ]
Reavill, Charlie [1 ]
机构：
[1] GlaxoSmithKline, Psychiat Ctr Excellence Drug Discovery, Harlow CM19 5AW, Essex, England
来源：
PHARMACOLOGY & THERAPEUTICS | 2008年 / 117卷 / 02期
关键词：
muscarinic receptors; mAChR; CNS; Alzheimer's disease; schizophrenia; Parkinson's disease; drug dependence;
D O I：
10.1016/j.pharmthera.2007.09.009
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Muscarinic acetylcholine receptors (mAChRs) are widely expressed in the CNS where they control a variety of neuronal functions. Due to their roles in a number of CNS processes, mAChRs have long been a target of the drug discovery industry; however, the only mAChR ligands approved for use in the clinic are non-selective antagonists for the treatment of Parkinson's disease. This article briefly reviews recent progress made in mAChR drug discovery for Alzheimer's disease (AD), schizophrenia and Parkinson's disease, with particular emphasis on novel target validation, as well as highlighting novel indications such as drug addiction. (c) 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码：232 / 243
页数：12
相关论文
共 50 条
  • [21] FUNCTION OF MUSCARINIC AND NICOTINIC ACETYLCHOLINE RECEPTORS
    PURVES, RD
    NATURE, 1976, 261 (5556) : 149 - 151
  • [22] Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development
    Jürgen Wess
    Richard M. Eglen
    Dinesh Gautam
    Nature Reviews Drug Discovery, 2007, 6 : 721 - 733
  • [23] Muscarinic acetylcholine receptors and airway diseases
    Coulson, FR
    Fryer, AD
    PHARMACOLOGY & THERAPEUTICS, 2003, 98 (01) : 59 - 69
  • [24] Allosteric modulation of muscarinic acetylcholine receptors
    Tucek, S
    Dolezal, V
    Jakubík, J
    Krejcíi, A
    Lysíková, M
    5TH CONGRESS OF THE EUROPEAN SOCIETY FOR CLINICAL NEUROPHARMACOLOGY, 2000, : 117 - 123
  • [25] MUSCARINIC ACETYLCHOLINE RECEPTORS OF DEVELOPING RETINA
    SUGIYAMA, H
    DANIELS, MP
    NIRENBERG, M
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (12) : 5524 - 5528
  • [26] Constitutive activity of muscarinic acetylcholine receptors
    Spalding, TA
    Burstein, ES
    JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION, 2006, 26 (1-2) : 61 - 85
  • [27] Allosteric modulation of muscarinic acetylcholine receptors
    Gregory, Karen J.
    Sexton, Patrick M.
    Christopoulos, Arthur
    CURRENT NEUROPHARMACOLOGY, 2007, 5 (03) : 157 - 167
  • [28] Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development
    Wess, Juergen
    Eglen, Richard M.
    Gautam, Dinesh
    NATURE REVIEWS DRUG DISCOVERY, 2007, 6 (09) : 721 - 733
  • [29] The conformational switch in muscarinic acetylcholine receptors
    Hulme, EC
    Lu, ZL
    Bee, M
    Curtis, CAM
    Saldanha, J
    LIFE SCIENCES, 2001, 68 (22-23) : 2495 - 2500
  • [30] Muscarinic acetylcholine receptors of the chick amnion
    B. N. Manukhin
    O. V. Boiko
    Biology Bulletin, 2008, 35 : 187 - 193
12345