A new coumarin from stem bark of Mesua hexapetala

被引：9
|
作者：
Karunakaran, Thiruventhan [1 ]
Ee, Gwendoline Cheng Lian [1 ]
Teh, Soek Sin [1 ]
Daud, Shaari [1 ,2 ]
Mah, Siau Hui [3 ]
Lim, Chan Kiang [4 ]
Jong, Vivien Yi Mian [5 ]
Awang, Khalijah [6 ]
机构：
[1] Univ Putra Malaysia, Dept Chem, Fac Sci, Serdang, Malaysia
[2] Univ Teknol MARA, Fac Appl Sci, Jengka, Malaysia
[3] Taylors Univ, Sch Biosci, Subang Jaya, Malaysia
[4] Univ Tunku Abdul Rahman, Dept Chem Sci, Fac Sci, Kampar, Malaysia
[5] Univ Teknol MARA, Ctr Appl Sci Studies, Kuching, Malaysia
[6] Univ Malaya, Dept Chem, Fac Sci, Kuala Lumpur, Malaysia
来源：
NATURAL PRODUCT RESEARCH | 2016年 / 30卷 / 14期
关键词：
Mesua hexapetala; coumarin; xanthone; anti-inflammatory; INHIBITORY-ACTIVITY; XANTHONES; FERREA; 4-PHENYLCOUMARINS; PYRANOXANTHONES; GUTTIFERAE;
D O I：
10.1080/14786419.2015.1120727
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A new alkylated coumarin derivative, hexapetarin (1) along with three other xanthones, trapezifolixanthone (2), cudraxanthone G (3) and 1,3,7-trihydroxy-2,4-di (3-methyl-2-butenyl) xanthone (4), and four common triterpenoids, friedelin (5), stigmasterol (6), betasitosterol (7) and gamma-sitosterol (8) were isolated from the stem bark of Mesua hexapetala (Clusiaceae), a plant, native to Malaysia. The structures of these compounds were elucidated and determined using spectroscopic techniques such as NMR and MS. Anti-inflammatory activity assay indicated hexapetarin (1) to possess moderate antiinflammatory activity, while 1,3,7-trihydroxy-2,4-di (3-methyl-2butenyl) xanthone (4) gave very good activity. [GRAPHICS] A new alkylated coumarin derivative, hexapetarin (1) along with three other xanthones, trapezifolixanthone (2), cudraxanthone G (3) and 1,3,7-trihydroxy-2,4-di (3-methyl-2-butenyl) xanthone (4) were isolated from the stem bark of Mesua hexapetala (Clusiaceae). The structures of these compounds were elucidated and determined using spectroscopic techniques such as NMR and MS.
引用
收藏
页码：1591 / 1597
页数：7
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