Rac-dependent and -independent pathways mediate growth factor-induced Ca2+ influx

被引：42
|
作者：
Peppelenbosch, MP
Tertoolen, LGJ
deVriesSmits, AMM
Qiu, RG
MRabet, L
Symons, MH
deLaat, SW
Bos, JL
机构：
[1] UNIV UTRECHT,PHYSIOL CHEM LAB,3584 CG UTRECHT,NETHERLANDS
[2] NETHERLANDS INST DEV BIOL,HUBRECHT LAB,3584 CT UTRECHT,NETHERLANDS
[3] ONYX PHARMACEUT,RICHMOND,CA 94806
来源：
JOURNAL OF BIOLOGICAL CHEMISTRY | 1996年 / 271卷 / 14期
关键词：
D O I：
10.1074/jbc.271.14.7883
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We report that expressing interfering mutants of the small Ras-related GTPase Rac, using either recombinant vaccinia virus or stable DNA transfection, eliminates epidermal growth factor-induced Ca2+ signaling, without affecting Ca2+ mobilization or influx from G protein-coupled receptors. Platelet-derived growth factor-dependent Ca2+ influx, however, is only partly sensitive to dominant negative Rac proteins. Thus, whereas epidermal growth factor-induced Ca2+ influx is completely mediated by Rac proteins, platelet-derived growth factor-induced Ca2+ influx involves Rac-dependent and -independent signaling pathways.
引用
收藏
页码：7883 / 7886
页数：4
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