Adoptive T-cell therapy in the treatment of viral and opportunistic fungal infections

被引：0

作者：

Mancini, Nicasio ^{[1
]}

Marrone, Lara ^{[1
]}

Clementi, Nicola ^{[1
]}

Sautto, Giuseppe A. ^{[1
]}

Clementi, Massimo ^{[1
]}

Burioni, Roberto ^{[1
]}

机构：

[1] Univ Vita Salute San Raffaele, Lab Microbiol & Virol, I-20132 Milan, Italy

来源：

FUTURE MICROBIOLOGY | 2015年 / 10卷 / 04期

关键词：

adoptive T-cell therapy; chimeric antigen receptor; fungal infections; immunocompromised patients; infectious diseases; T cell; T-cell receptor; viral infections; PERIPHERAL-BLOOD LYMPHOCYTES; CHIMERIC ANTIGEN RECEPTOR; HEPATITIS-C; MONOCLONAL-ANTIBODIES; ASPERGILLUS-FUMIGATUS; MOLECULAR-CLONING; IMMUNE-RESPONSES; DENDRITIC CELLS; HCV INFECTION; GENE-TRANSFER;

D O I：

10.2217/FMB.14.122

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Viral infections and opportunistic fungal pathogens represent a major menace for immunocompromised patients. Despite the availability of antifungal and antiviral drugs, mortality in these patients remains high, underlining the need of novel therapeutic options based on completely different strategies. This review describes the potential of several T-cell-based therapeutic approaches in the prophylaxis and treatment of infectious diseases with a particular focus on persistent viral infections and opportunistic fungal infections, as these mostly affect immunocompromised patients.

引用

页码：665 / 682

页数：18

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