OCT4 gonadal gene expression related to the presence of Y-chromosome sequences in Turner syndrome

被引：13
|
作者：
Bianco, Bianca [1 ,2 ]
Oliveira, Kelly C. [1 ]
Guedes, Alexis D. [1 ]
Barbosa, Caio P. [2 ]
Lipay, Monica V. N. [1 ]
Verreschi, Ieda T. N. [1 ]
机构：
[1] Univ Fed Sao Paulo, Dept Med, Div Endocrinol, Sao Paulo, Brazil
[2] ABC Sch Med, Dept Gynecol & Obstet, Div Gynecol Pathol & Human Reprod, Santo Andre, Brazil
来源：
FERTILITY AND STERILITY | 2010年 / 94卷 / 06期
基金：
巴西圣保罗研究基金会;
关键词：
Turner syndrome; gonadal dysgenesis; OCT4; gene; SRY gene; TSPY gene; Y-chromosome; GONADOBLASTOMA;
D O I：
10.1016/j.fertnstert.2010.02.036
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
To show that in the dysgenetic gonads of 104 Turner syndrome patients no significant difference was found regarding the expression of the genes DAX1, FOG2, GATA4, OCT4, SF1, SRY, TSPY, WT1, and STRA8 compared with controls, except for genes OCT4, SRY, and TSPY in both gonads of a patient whose chromosomal constitution was 45,X/45,X,add(15)(p11). The expression analysis of genes OCT4, SRY, and TSPY in the dysgenetic gonads of Turner syndrome patients may allow introducing modifications in the microenvironment that could contributed to a malignant transformation process. (Fertil Steril (R) 2010;94:2347-9. (C) 2010 by American Society for Reproductive Medicine.)
引用
收藏
页码：2347 / 2349
页数：3
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