SYNTHESIS AND NEUROTROPIC ACTIVITY OF 6-THIO-SUBSTITUTED PYRANO[3,4-c]PYRIDINE AND 1-AMINOPYRANO[4,3-d]-THIENO[2,3-b]PYRIDINE DERIVATIVES AND 9-SUBSTITUTED PYRIDO[2,3-b]THIENO[3,2-d]PYRIMIDINES

被引：7

作者：

Paronikyan, E. G. ^{[1
]}

Akopyan, Sh. F. ^{[1
]}

Noravyan, A. S. ^{[1
]}

Dzhagatspanyan, I. A. ^{[1
]}

Nazaryan, I. M. ^{[1
]}

Akopyan, A. G. ^{[1
]}

机构：

[1] Natl Acad Sci Armenia, AI Mndzhoyan Fine Organ Chem Inst, Yerevan, Armenia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2010年 / 44卷 / 04期

关键词：

pyrano[3,4-c]pyridines; thieno[3,2-d]pyrimidines; neurotropic activity; anticonvulsive activity; diazepam; cyclization; condensation;

D O I：

10.1007/s11094-010-0426-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Methods for the synthesis of condensed thieno[3,2-d]pyrimidines based on 3,3-dimethyl-8-morpholino-6-thioxo-3,4,6,7-tetrahydro-1H-pyrano[3,4-c]pyridine-5-y1 cyanide have been developed. The neurotropic properties of the synthesized compounds have been investigated. Compounds possessing anticonvulsant activity and sedative properties are found. These compounds also exhibit an activating effect that makes them analogous to the well-known drug diazepam.

引用

页码：183 / 185

页数：3

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