Sexual dimorphism in the vasopressin system: Lack of an altered behavioral phenotype in female V1a receptor knockout mice

被引：63
|
作者：
Bielsky, IE [1 ]
Hu, SB
Young, LJ
机构：
[1] Emory Univ, Dept Psychiat, Atlanta, GA 30329 USA
[2] Emory Univ, Ctr Behav Neurosci, Atlanta, GA 30329 USA
[3] NIMH, Clin Neuroendocrinol Branch, NIH, Bethesda, MD 20892 USA
来源：
BEHAVIOURAL BRAIN RESEARCH | 2005年 / 164卷 / 01期
关键词：
vasopressin; V1a receptor; anxiety; neuropeptides; females; sexual dimorphism;
D O I：
10.1016/j.bbr.2005.06.005
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Previous findings with an AVP V1a receptor knockout mouse (V1aRKO) demonstrate a significant role for this receptor in anxiety-like behavior in males. Here we report the lack of anxiety-like effects of the null mutation in female mice. V1aRKO females performed normally on all tests for anxiety-like behavior. This sex difference may be due to the sexual dimorphism in the extra-hypothalamic vasopressin system, with males having significantly more vasopressin fibers in this system. (c) 2005 Published by Elsevier B.V.
引用
收藏
页码：132 / 136
页数：5
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