Swine Dental Pulp Stem Cells Inhibit T-Cell Proliferation

被引：16
|
作者：
Tang, R. [1 ]
Ding, G. [1 ]
机构：
[1] Weifang Med Univ, Dept Stomatol, Yidu Cent Hosp, Qingzhou 262500, Peoples R China
来源：
TRANSPLANTATION PROCEEDINGS | 2011年 / 43卷 / 10期
基金：
中国国家自然科学基金;
关键词：
VERSUS-HOST-DISEASE; BONE-MARROW; LYMPHOCYTE-PROLIFERATION; APICAL PAPILLA; STROMAL CELLS; IN-VITRO; REGENERATION; SUPPRESSION; ARTHRITIS; THERAPY;
D O I：
10.1016/j.transproceed.2011.08.102
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Dental pulp stem cells (DPSCs) hold great promise for tooth regeneration and dental diseases. To expand the source of DPSCs and explore the feasibility of allogeneic usefulness of DPSCs, we investigated its immunogenicity and its immunomodulatory effects on T lymphocytes. The results showed that DPSCs failed to stimulate allogeneic T-cell proliferation. In addition, they significantly inhibited phytohemagglutinin-triggered T-cell proliferation and one-way mixed lymphocytes reactions. Soluble factor(s) may play important role in the immunosuppressive process. DPSCs have low immunogenicity and immunomodulatory actions on T lymphocytes, which may expand the source of DPSCs and reinforce the therapeutic interest in DPSCs.
引用
收藏
页码：3955 / 3959
页数：5
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