Eukaryotic 5S rRNA biogenesis

被引：122
|
作者：
Ciganda, Martin [1 ]
Williams, Noreen [1 ]
机构：
[1] SUNY Buffalo, Dept Microbiol & Immunol, Buffalo, NY 14260 USA
来源：
WILEY INTERDISCIPLINARY REVIEWS-RNA | 2011年 / 2卷 / 04期
关键词：
TRANSCRIPTION FACTOR IIIA; COMPARATIVE STRUCTURAL-ANALYSIS; SACCHAROMYCES-CEREVISIAE; TRYPANOSOMA-BRUCEI; PROTEIN L5; ESCHERICHIA-COLI; BINDING-PROTEINS; NUCLEAR EXPORT; LA PROTEIN; XENOPUS-OOCYTES;
D O I：
10.1002/wrna.74
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The ribosome is a large complex containing both protein and RNA which must be assembled in a precise manner to allow proper functioning in the critical role of protein synthesis. 5S rRNA is the smallest of the RNA components of the ribosome, and although it has been studied for decades, we still do not have a clear understanding of its function within the complex ribosome machine. It is the only RNA species that binds ribosomal proteins prior to its assembly into the ribosome. Its transport into the nucleolus requires this interaction. Here we present an overview of some of the key findings concerning the structure and function of 5S rRNA and how its association with specific proteins impacts its localization and ;function. (C) 2011 John Wiley & Sons, Ltd. WIREs RNA 2011 2 523-533 DOI:10.1002/wrna.74
引用
收藏
页码：523 / 533
页数：11
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