Study of the interaction of β-cyclodextrin with albendazole in aqueous solutions

被引：10

作者：

Stepniak, A. ^{[1
]}

Buczkowski, A. ^{[1
]}

Zavodnik, L. ^{[2
]}

Belica-Pacha, S. ^{[1
]}

Palecz, B. ^{[1
]}

机构：

[1] Univ Lodz, Unit Biophys Chem, Dept Phys Chem, Fac Chem, Pomorska 165, PL-90236 Lodz, Poland

[2] Grodno State Agr Univ, Dept Pharmacol & Physiol, Volkovich St 1, Grodno 230023, BELARUS

来源：

JOURNAL OF MOLECULAR LIQUIDS | 2017年 / 248卷

关键词：

beta-Cydodextrin; Albendazole; Isothermal titration calorimetry (ITC); UV-VIS spectroscopy; SOLUBILITY; CELLS; 5-FLUOROURACIL; COMPLEXATION; SHEEP;

D O I：

10.1016/j.molliq.2017.09.100

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

We performed calorimetric titration (ITC) measurements of aqueous albendazole solutions with aqueous beta-cyclodextrin solutions. The obtained results were used to determine the enthalpy and entropy of the drug-beta-cyclodextrin interaction, the stoichiometry of the resulting inclusion complex and its formation constant. Using the UV spectrophotometer, we determined the solubility of albendazole in water, as well as the increase of the drug solubility driven by the increase of beta-cyclodextrin concentration. Biological studies carried out on mouse cultures confirmed an increase of the albendazole-beta-cyclodextrin complex bioavailability, as compared to the uncomplexed drug. (c) 2017 Elsevier B.V. All rights reserved.

引用

页码：19 / 23

页数：5

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