Chemically induced rat mammary tumor treated with tamoxifen showed decreased expression of cyclin D1, cyclin E, and p21Cip1

被引：6
|
作者：
Jang, TJ
Park, JH
Cho, MY
Kim, JR
机构：
[1] Donnguk Univ, Coll Med, Dept Pathol, Kyongbuk 780714, South Korea
[2] Yonsei Univ, Wonju Coll Med, Dept Pathol, Kangwon Do 220701, South Korea
来源：
CANCER LETTERS | 2001年 / 170卷 / 02期
关键词：
mammary tumor; cyclin D1; cyclin E; p21(Cip1); tamoxifen;
D O I：
10.1016/S0304-3835(01)00593-6
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We studied the effects of tamoxifen (TAM) on the growth of 7,12-dimethylbenz(a)anthracene (DMBA)-induced rat mammary tumor and the expression of cyclin DI, cyclin E, p21(Cip1), and estrogen receptors (ER) by performing immunohistochemistry and Western blot analysis. When tumor size reached between 10 and 15 nim. in the largest dimension, the rats were divided into a DMBA-control group and a DMBA-TAM group. The administration of TAM markedly decreased the tumor development and showed decreased expression of bromodeoxyuridine, cyclin D1, cyclin E, and p21(Cip1) when compared with those of the DMBA-control group; however, a few tumors showed progressive growth in spite of TAM treatment. These tumors had decreased expression of ER. This study suggests that TAM suppresses tumor development through the down-expression of cyclin D1 and cyclin E. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：109 / 116
页数：8
相关论文
共 50 条
  • [41] Expression of cyclin D1, cyclin E and p27KIP1 in schistosomal versus nonschistosomal bladder cancer
    Khan, AA
    Chaudhary, KS
    Abel, PD
    Shoma, AM
    El Baz, M
    Stamp, GWH
    Lalani, EN
    BRITISH JOURNAL OF CANCER, 2000, 83 : 59 - 59
  • [42] Reactive oxygen species-mediated cyclin D1 degradation mediates tumor growth retardation in hypoxia, independently of p21cip1 and hypoxia-inducible factor
    Lim, Ji-Hong
    Lee, Yoon-Mi
    Chun, Yang-Sook
    Park, Jong-Wan
    CANCER SCIENCE, 2008, 99 (09) : 1798 - 1805
  • [43] IGF-1 increases laminin, cyclin D1, and p21Cip1 expression in glomerular mesangial cells:: An investigation of the intracellular signaling pathway and cell-cycle progression
    Jiang, Y
    Cheng, DW
    Levi, E
    Singh, LP
    JOURNAL OF CELLULAR BIOCHEMISTRY, 2006, 98 (01) : 208 - 220
  • [44] Mitotic p21Cip1/CDKN1A is regulated by cyclin-dependent kinase 1 phosphorylation
    Kreis, Nina-Naomi
    Friemel, Alexandra
    Zimmer, Brigitte
    Roth, Susanne
    Rieger, Michael A.
    Rolle, Udo
    Louwen, Frank
    Yuan, Juping
    ONCOTARGET, 2016, 7 (31) : 50215 - 50228
  • [45] Effect of energy restriction on the expression of cyclin D1 and p27 during premalignant and malignant stages of chemically induced mammary carcinogenesis
    Zhu, ZJ
    Jiang, WQ
    Thompson, HJ
    MOLECULAR CARCINOGENESIS, 1999, 24 (04) : 241 - 245
  • [46] Prognostic significance of cyclin D1 and p21 (WAF1/CIP1) in Gastric Cancer
    Michalaki, V.
    Theodosopoulos, T.
    Dafnios, N.
    Vezakis, A.
    Karvouni, E.
    Papadimitriou, C.
    ANNALS OF ONCOLOGY, 2016, 27 : 4 - 4
  • [47] Suppression of arthritis by forced expression of cyclin-dependent kinase inhibitor p21Cip1 gene into the joints
    Nonomura, Y
    Kohsaka, H
    Nasu, K
    Terada, Y
    Ikeda, M
    Miyasaka, N
    INTERNATIONAL IMMUNOLOGY, 2001, 13 (06) : 723 - 731
  • [48] The expression of Cyclin A and p21cip1in fibroblast of hypertrophic scar
    金文虎
    China Medical Abstracts(Surgery), 2011, 20 (02) : 131 - 131
  • [49] ErbB-2-induced mammary tumor growth: the role of cyclin D1 and p27Kip1
    Hulit, J
    Lee, RJ
    Russell, RG
    Pestell, RG
    BIOCHEMICAL PHARMACOLOGY, 2002, 64 (5-6) : 827 - 836
  • [50] Activation of cyclin D1-kinase in murine fibroblasts lacking both p21Cip1 and p27Kip1
    Masataka Sugimoto
    Nicholas Martin
    Deepti P Wilks
    Katsuyuki Tamai
    Thomas JG Huot
    Cristina Pantoja
    Ko Okumura
    Manuel Serrano
    Eiji Hara
    Oncogene, 2002, 21 : 8067 - 8074
12345