Functional Impairment in the Diagnosis of Mild Cognitive Impairment

被引：9

作者：

Han, Ji Won ^{[1
]}

Lee, Seok Bum ^{[2
]}

Kim, Tae Hui ^{[1
]}

Park, Joon Hyuk ^{[3
]}

Lee, Jung Jae ^{[4
]}

Huh, Yoon Seok ^{[1
]}

Choi, Eun Ae ^{[5
]}

Choe, Jin Yeong ^{[1
]}

Do, Yeon Ja ^{[1
]}

Lee, Dong Young ^{[6
,7
]}

Kim, Ki Woong ^{[1
,6
]}

机构：

[1] Seoul Natl Univ, Bundang Hosp, Dept Neuropsychiat, Songnam 463707, Gyeonggido, South Korea

[2] Dankook Univ Hosp, Dept Psychiat, Chungcheongnamdo, South Korea

[3] Jeju Natl Univ Hosp, Dept Neuropsychiat, Jejudo, South Korea

[4] Kyungbook Natl Univ Hosp, Dept Psychiat, Taegu, South Korea

[5] Yesarang Hosp, Dept Psychiat, Chungcheongbukdo, South Korea

[6] Seoul Natl Univ, Coll Med, Dept Psychiat, Seoul, South Korea

[7] Seoul Natl Univ Hosp, Dept Neuropsychiat, Seoul 110744, South Korea

来源：

ALZHEIMER DISEASE & ASSOCIATED DISORDERS | 2011年 / 25卷 / 03期

关键词：

mild cognitive impairment; functional activity; diagnostic criteria; predictive validity; dementia; INSTRUMENTAL ACTIVITIES; ALZHEIMERS-DISEASE; COMPLEX ACTIVITIES; DEMENTIA; PROGRESSION; PREVALENCE; CRITERIA; SCALE;

D O I：

10.1097/WAD.0b013e318209d517

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The criterion on functional activity in the revised diagnostic criteria for mild cognitive impairment (MCI) seems to be conceptually and operationally problematic. We investigated the predictive validity for dementia of this criterion in 140 patients with MCI who participated in the baseline study of the Korean Longitudinal Study on Health and Aging and completed 18-month follow-up evaluation (mean duration of follow-up, 1.57 +/- 0.24 y). Annual conversion rates to dementia were compared between the patients who fulfilled the criterion on functional activity and those who did not. Annual conversion rates to dementia of the patients who fulfilled the criterion on functional activity was 4.76%, whereas that of the patients with MCI who did not was 33.07%, indicating that the criterion on functional activity was a significant negative predictor of dementia (odds ratio = 0.12). Re-revision of the criterion on functional activity may be warranted to solve its conceptual and operational ambiguities.

引用

页码：225 / 229

页数：5

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