Pharmacogenetic differentiation across Latin America

被引：7
|
作者：
Suarez-Kurtz, Guilherme [1 ]
de Araujo, Gilderlanio Santana [2 ]
机构：
[1] Inst Nacl Canc, Div Pesquisa Clin & Desenvolvimento Tecnol, Rio De Janeiro, Brazil
[2] Univ Fed Para, Inst Ciencias Biol, Programa Posgrad Genet & Biol Mol, Belem, Para, Brazil
来源：
PHARMACOGENOMICS | 2022年 / 23卷 / 04期
关键词：
biogeographical ancestry; fixation index statistics; Latin America population; pharmacogenetic differentiation; population admixture; POPULATION DIVERSITY; POLYMORPHISMS; GENOTYPE;
D O I：
10.2217/pgs-2021-0152
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Aim: To explore the pharmacogenetic differentiation across Latin American populations, using the fixation index statistics (F-ST). Materials & methods: F-ST analyses were applied to 1519 pharmacogenetic markers in the 1000 Genomes Admixed American superpopulation (1KG_AMR) and an admixed Brazilian sample. Results: Allele-specific F-ST values for the overall cohort point to little overall pharmacogenetic differentiation (average F-ST = 0.017); however, moderate differentiation (F-ST = 0.05-0.15) was observed for 83 markers, while large differentiation (F-ST = 0.15-0.25) was restricted to three markers. Pairwise F-ST analysis identified three markers with very large differentiation (F-ST >0.25). Conclusion: The present study verifies and extends previous reports of little overall pharmacogenetic divergence across Latin America, although a number of markers display substantial differentiation.
引用
收藏
页码：225 / 233
页数：10
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